Putting a New Spin of G4 Structure and Binding by Analytical Ultracentrifugation
William L. Dean, Robert D. GrayiD, Lynn DeLeeuw, Robert C. MonseniD, Jonathan B. ChairesiD
Abstract
Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of how it can be used to characterize G4 formation and to monitor small-molecule binding.
02 /Specification & Classification
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