Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants

Frank R. Wendt; Antonella De Lillo; Gita A. Pathak; Flavio De Angelis; COVID-19 Host Genetics Initiative; Renato Polimanti

doi:10.3389/fgene.2021.765247

Genetic & Genomic MedicineFrontiers in GeneticsDec 13, 2021

Peer-reviewed journal article

Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants

Frank R. Wendt iD, Antonella De Lillo iD, Gita A. Pathak iD, Flavio De Angelis iD, COVID-19 Host Genetics Initiative, Renato Polimanti iD

Abstract

To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N>1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use, and alcohol use. COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors.

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