Genetic correlations between COVID-19 and a variety of diseases and other medically relevant traits
Xiao ChangiD, Yun LiiD, Kenny NguyeniD, Hui‐Qi QuiD, Yichuan LiuiD, Joseph GlessneriD, Patrick M. Abou‐SleimaniD, Hakon H. HakonarsoniD
Abstract
We analyzed GWAS results released by COVID-19 Host Genetics Initiative, UK biobank and GWAS Catalog to explore the genetic overlap between COVID-19 and a broad spectrum of traits and diseases. We validate previously reported medical conditions and risk factors based on epidemiological studies, including but not limited to hypertension, type 2 diabetes and obesity. We also report novel traits associated with COVID-19, which have not been previously reported from epidemiological data, such as opioid use and educational attainment. Taken together, this study extends our understanding of the genetic basis of COVID-19, and provides target traits for further epidemiological studies.
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