Flavio De Angelis

On the Edge of Empire: Paleogenomic Insights into Roman Dacia

This study uses genomic data from Roman Dacia to show sex-biased ancestry patterns, indicating male-mediated gene flow and complex demographic interactions in Roman frontier communities.

The Genomic Legacy of the Norman Conquest in Rural England

This study analyzes ancient DNA from a rural English cemetery to explore genetic continuity and change following the Norman Conquest, finding no genome-wide discontinuity.

Temporal shifts in polygenic traits track major epidemics in Western Eurasia

The paper tracks shifts in polygenic traits linked to infectious diseases across 10,000 years in Western Eurasia, showing associations with major historical epidemics.

Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.

This study investigates sex differences in the genetic pleiotropy between hearing difficulty and brain imaging-derived phenotypes using large-scale GWAS data and multiple analytical methods.

Sex differences, cross-ancestry generalizability, and noise-smoking interactions in the polygenic architecture of hearing loss in adults

This study identifies 54 risk loci for hearing loss in adults across multiple cohorts, revealing sex differences, ancestry-specific polygenic risks, and interactions with environmental factors like noise and smoking.

Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program

This study analyzes ancestry diversity changes in the Million Veteran Program over time and shows that refined ancestry modeling reduces population stratification in GWAS of height.

The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic Transthyretin expression

This paper integrates genetic transcriptomics and electronic health records to show increased hepatic Transthyretin expression is linked to specific surgical procedures and health outcomes like osteoarthritis and carpal tunnel syndrome.

Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants

The paper investigates genetic correlations between severe COVID-19 and traits like alcohol use and diabetes in over 1 million participants, showing genetic links and potential causality.

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use.

The paper investigates the association between polygenic risk scores for drinking and smoking behaviors and neurodevelopmental outcomes in children and young adults, finding independent effects from psychopathology and substance use.

ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility

The paper functionally characterizes the ACE2 gene network to identify potential mechanisms of COVID-19 susceptibility and drug-gene interactions.

The impact of evolutionary processes in shaping the genetics of complex traits in East Asia and Europe: a specific contribution from Denisovan and Neanderthal introgression

The paper investigates how evolutionary processes, including Denisovan and Neanderthal introgression, affect the genetics of complex traits in East Asians using genome-wide association data.

Epigenomic profiles of African American Transthyretin Val122Ile carriers reveals putatively dysregulated amyloid mechanisms

This study identifies epigenomic changes in African American Transthyretin Val122Ile carriers linked to heart disease and outpatient surgeries, revealing dysregulated amyloid mechanisms.

Epigenetic profiling of Italian patients identified methylation sites associated with hereditary Transthyretin amyloidosis

The paper identifies methylation sites associated with hereditary Transthyretin amyloidosis through an epigenome-wide association study.

Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and senile systemic amyloidoses

This study identifies novel associations between TTR and RBP4 gene variants and multiple phenotypes related to hereditary and senile systemic amyloidoses in a large cohort.