This study harmonizes RNA-Seq data from multiple SCC studies to define a consensus gene expression landscape, identifies UV-responsive genes, and shows gene fusions are not common drivers of SCC.

bioRxiv · Dec 11, 2023Cancer Biology

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

A. Srivastava, C. Tommasi, D. Sessions, A. Mah, T. Bencomo, J. M. Garcia, T. Jiang, M. Lee, J. Y. Shen, L. W. Seow, A. Nguyen, K. Rajapakshe, C. Coarfa, K. Y. Tsai, V. Lopez-Pajares, C. S. Lee

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

bioRxiv · Jan 19, 2022 · PreprintCancer Biology

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

F. T. Lee-Montiel, A. Laemmle, L. Dumont, C. S. Lee, N. Huebsch, V. Charwat, H. Okochi, M. J. Hancock, B. Siemons, S. C. Boggess, I. Goswami, E. Miller, H. Willenbring, K. Healy

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

bioRxiv · May 24, 2020 · PreprintBioengineering

High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

O.-H. Kim, C. J. Booth, H. S. Choi, J. Lee, J. Kang, J. Hur, H. J. Choi, H. Kim, J.-H. Auh, J.-Y. Cha, Y. J. Lee, C. S. Lee, C. Choi, J.-y. Yang, S.-S. Im, , B.-C. Oh

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

bioRxiv · Oct 29, 2019Physiology