bioRxivNeurosciencePreprint
Time-dependent roles of adolescent- and adult-born dentate granule neurons in spatial learning
Núria MasachsiD, Vanessa CharrieriD, Fanny Farrugia, Valérie Lemaire, Wilfrid MazieriD, Nicolas BliniD, Sophie TroneliD, Marie‐Françoise Montaron, Shaoyu GeiD, Daniela CotaiD, Véronique Deroche‐GamonetiD, Cyril HerryiD, Djoher Nora AbrousiD
Abstract
The dentate gyrus presents the peculiarity to be formed after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated and compared the role of dentate neurons born during adolescence or generated during adulthood. We demonstrated that the ontogenetic stage of dentate neurons in relation to when they are generated dictates their participation in memory processes.
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