bioRxivNeurosciencePreprint
A mobile circular DNA element drives memory-related processes in mice
Haobin ReniD, Hao GongiD, Wei-Siang LiauiD, Qiongyi ZhaoiD, Alexander P. WalshiD, Mason R.B. MusgroveiD, Joshua W.A. DaviesiD, Esmi L. ZajackowskiiD, Sachithrani U. MadugalleiD, Paul R. MarshalliD, Tian Lan, Jichun ShiiD, Jiazhi JiangiD, Wei WeiiD, Xiang LiiD, Timothy W. BredyiD
Abstract
Extrachromosomal circular DNAs (ecDNAs) are double stranded, closed loop DNA molecules that act independently of the genome. Here we report the discovery of a brain-enriched ecDNA, ecCldn34d, that regulates the transcriptional state of plasticity-related genes and is temporally associated with the stability of fear memories. ecDNA therefore represents a novel class of mobile DNA elements that are involved in experience-dependent neuroadaptation.
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