Joshua Davies

Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

Light-inducible proximity labelling in vivo captures sex-specific RNA at excitatory synapses

PSD-95-Halo-seq combined with long-read sequencing reveals sex-specific RNA isoform remodeling in excitatory synapses following fear learning.

Local translation of circular RNAs is required for synaptic activity and memory

The paper identifies local translation of circular RNAs in the prefrontal cortex of mice, revealing a micropeptide involved in synaptic activity and memory.

A mobile circular DNA element drives memory-related processes in mice

The paper identifies a brain-enriched extrachromosomal circular DNA (ecDNA) that regulates plasticity-related genes and is linked to fear memory stability in mice.

DNA G-quadruplex is a transcriptional control device that regulates memory

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

Fear extinction is regulated by long noncoding RNA activity at the synapse

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

Inhibiting circRNA Cdr1as expression in the ILPFC of adult male C57BL/6J mice impairs fear extinction memory

The paper shows that inhibiting circRNA Cdr1as in the infralimbic prefrontal cortex of mice impairs fear extinction memory.

Discovery of synapse-specific RNA N6-methyladenosine readers associated with the consolidation of fear extinction memory

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.