A Bayesian approach to inferring chemical signal timing and amplitude in a temporal logic gate using the cell population distributional response

Abstract

1. Introduction 1. Introduction 2. The temporal logic... 3. Bayesian event detection... 4. Applying the Bayesian... 5. Conclusion References Stochastic gene expression poses an important challenge for engineering robust behaviors in a heterogeneous cell population [1]. Cells address this challenge using the distribution of cellular responses during some gene regulation and differentiation processes [2]. Similarly, the temporal logic gate design in Hsiao et al. [3] considers the distribution of responses across a cell population. The design employs integrases Bxb1 and TP901-1 [4] to engineer an E. coli strain with four DNA states that record the temporal order of two chemical signals. Hsiao et al. [3] also use the heter ...