K. Thurley

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

Diffusion-limited cytokine signaling in T cell populations

This study uses simulations to show that spatial cytokine inhomogeneities in T cell populations are critical for paracrine signaling and depend on cell population properties and feedback mechanisms.

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells

This study analyzes the dynamic transcriptome of Th cell differentiation, revealing a unique STAT-dependent transcriptional program in Th1/2 hybrid cells.

Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction

The paper shows that tissue-resident memory CD4+ T cells mobilize into the blood after vaccination and contribute to systemic secondary immune responses.

Response-Time Behaviors Of Intercellular Communication Network Motifs

The paper models cell-to-cell communication networks using response-time distributions to explain cytokine secretion onset times in T cells and predict network structure from input-output measurements.