Culture conditions antagonize lineage-promoting signaling in the mouse blastocyst
Abstract
The mouse preimplantation embryo is a paradigm for discovery of the molecular principles governing formation of specific cell types during development. We show that conditions commonly used for ex vivo culture of preimplantation development are themselves antagonistic to a pathway that is critical for blastocyst lineage commitment.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 6
- FWCI
- 0.49
- Field percentile
- top 44%
- Organism
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Fracking and Ostwald ripening position the lumen of the mouse blastocyst
Julien G. Dumortier, Mathieu Le Verge-Serandour, … Jean‐Léon Maître·SciencePeer-reviewed·Aug 1, 2019
- Dynamic coupling of cell fate specification and cell sorting during mouse preimplantation development
Sascha Ollertz, Silvia Muñoz Descalzo, Sabine Fischer·bioRxiv·Sep 2, 2026
- A robust ex vivo system to study cellular dynamics underlying mouse peri-implantation development
Takafumi Ichikawa, Hui Ting Zhang, … Takashi Hiiragi·Developmental CellPeer-reviewed·Jan 20, 2022
- Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids.
Erik Vrij, Yvonne Scholte op Reimer, … Nicolas C. Rivron·bioRxiv·Apr 12, 2019
- In Vitro Culture Alters Cell Lineage Composition and Cellular Metabolism of Bovine Blastocyst
Hao Ming, Mingxiang Zhang, … Ye Yuan·Biology of ReproductionPeer-reviewed·Feb 26, 2024
- Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
Robin E. Kruger, Tristan Frum, … Amy Ralston·bioRxiv·Jan 23, 2024