Mosquito-borne diseases and control

The paper uses Nanopore sequencing to analyze DENV-2 in Tanzanian mosquitoes, finding a distinct clade related to Asian strains and identifying intra-host variants, suggesting a silent introduction of genotype II.

This study identifies stable temperature and humidity combinations that correlate with dengue outbreaks in Ahmedabad, India, over a ten-year period.

This study identifies nsP3-RBP co-condensation as a mechanism alphaviruses use to sustain replication, showing disruption of these condensates can inhibit viral replication.

DENcode estimates transmission probabilities between dengue cases using genetic and epidemiological data, revealing key transmission roles and network structures.

This study identifies novel small-molecule inhibitors of Chikungunya virus replication through high-throughput screening and characterizes their mechanism of action and resistance profiles.

This study evaluates the direct and indirect effects of targeted indoor residual spraying (TIRS) on Aedes aegypti density in Iquitos, Peru, finding significant reductions at 15 days and sustained effects up to 255 days.

The paper develops a neural network framework to predict the presence and weekly abundance of Aedes albopictus across Europe using climate variables.

The paper monitors Ae. albopictus egg density over three years in Montpellier, finding vegetation structure, growing degree days, and lagged egg counts influence egg density dynamics.

This study shows UV exposure increases susceptibility to arboviruses by altering skin cell states and enhancing mosquito probing.

The paper detects and phylogenetically characterizes Jingmen tick virus in Amblyomma mixtum ticks from Costa Rica, identifying two distinct clades and suggesting potential human relevance.

The paper assesses the vector competence of several mosquito species for Madariaga virus, finding that some species can transmit it while others cannot.

The paper develops a process-based model to predict the spatial-temporal occurrence of Culex pipiens s.s./Cx. torrentium in Germany, accurately capturing phenology and overwintering behavior.

This study compares DENV-2 and DENV-4 infection kinetics and immune responses in human tonsil histocultures, showing DENV-4 replicates faster and activates innate immunity more strongly.

The paper establishes classification criteria for jingmenviruses using genomic sequences from metagenomics data to define species demarcation thresholds.

This paper reviews laboratory-confirmed vector competence of Anopheles mosquitoes for arboviruses, finding some species act as secondary vectors and may contribute to virus overwintering.

This study introduces the Empirical Persistence Threshold (EPT) to analyze pathogen persistence in urban systems, finding that persistence depends on population size, climate, and urban connectivity rather than a single threshold.

The paper measures microclimates of Culex mosquito breeding sites in an urban desert and finds they are cooler than macroclimates, suggesting better thermal buffering for larvae.

This study shows that dengue protease activates and polarizes macrophages towards M1 phenotype without toxicity, suggesting potential for macrophage-based therapies.

This study identifies natural YFV infection in Sabethes albiprivus in southern Brazil, highlighting its potential role as a secondary vector and emphasizing the need for enhanced surveillance and vaccination.

This study compares Aedes aegypti population dynamics and arboviral risks between peri-urban and intra-urban villages during dengue outbreaks in Cote d'Ivoire, finding high mosquito densities and elevated epidemic indices in both areas.

This study investigates how the DENV capsid protein interacts with single-stranded DNA, revealing structural changes that suggest molecular condensation and potential phase separation in complex formation.

This paper estimates the temperature-dependent extrinsic incubation period (EIP) of Usutu virus in Culex pipiens molestus, showing it is shorter than West Nile virus, suggesting USUV could precede WNV in Europe.

This study identifies an IgG3 subclass antibody that expands neutralization breadth against dengue and zika viruses by engaging a quaternary epitope through structural and functional analyses.

This study identifies structural features of broadly neutralizing antibodies against dengue virus that target conserved epitopes across serotypes.

This study identifies that ZIKV upregulates PTBP1 via HIF-1alpha, which then binds NS1 to promote its degradation, thereby inhibiting viral replication.

This study investigates the role of the crown protein in OmRV infection and transmission, finding it dispensable for entry but required for efficient cell-to-cell spread.

The paper identifies novel host factors interacting with TBEV RNA through an RNA-centric screen, revealing both proviral and antiviral proteins involved in viral replication and immune evasion.

This paper evaluates lauric acid's antiviral effect against DENV-2 using a replicon assay, finding it inhibits viral replication with an IC50 of 1.70 uM, comparable to mycophenolic acid.

This study investigates VEEV TC-83 infection's impact on hIPSC-derived cardiomyocytes, revealing cardiac dysfunction and heart failure biomarker secretion.

This study evaluates AddaS03 as an adjuvant for a WNV subunit vaccine, showing it elicits higher neutralizing antibody titers and provides full protection in mice compared to Alhydrogel.