Mosquito-borne diseases and control

This study analyzes spatiotemporal patterns of Aedes aegypti and Culex quinquefasciatus in Miami-Dade County over eight years to identify population hotspots and seasonal trends for public health planning.

This study identifies host cellular pathways perturbed by TBEV infection and highlights potential antiviral targets.

This study uses single-cell RNA-sequencing to analyze skin responses to West Nile virus-infected mosquito bites, identifying fibroblasts as key cells restricting viral transmission.

This paper presents a machine learning model predicting global monthly habitat suitability for Aedes aegypti and Aedes albopictus from 1975 to 2024, showing expanded suitable areas now covering over 5 billion people.

This study assesses how lab storage conditions affect physicochemical changes in field-collected mosquito breeding water, finding that ambient humidity and temperature significantly influence these changes.

This study examines how climate-driven thermal changes affect an invasive temperate mosquito's vector competence for dengue and chikungunya viruses, revealing stage- and pathogen-specific thermal responses.

This study shows that dengue virus NS1 partially translocates to the nucleus, modulating host transcription and supporting viral replication.

This paper evaluates using low-cost smartphone imaging with geometric wing morphometrics to accurately identify invasive Aedes mosquito species, finding it reliable but with higher observer variability compared to professional microscopes.

This study produces Dengue-1 virus-like particles in HeLa cells that induce strong antibody responses in mice, suggesting their potential as a vaccine candidate and serodiagnostic tool.

The paper compares host-seeking behavior and post-blood meal suppression across Aedes, Anopheles, and Culex mosquitoes, identifying interspecific differences in behavioral patterns.

The paper identifies two human monoclonal antibodies that neutralize West Nile virus and related orthoflaviruses, offering potential for antibody-based interventions.

This paper identifies eIF4A as a druggable host factor in insect vectors that can be targeted by rocaglates and pateamines to suppress arboviral replication.

This paper identifies potent benzamide compounds against Zika virus by targeting NS4B, showing superior potency and novel resistance mutation patterns compared to existing treatments.

This study shows that temephos, a pesticide, changes how Aedes aegypti mosquitoes respond to temperature, reducing survival and altering population growth rates.

This study shows DDX3X promotes ZIKV replication in human microglia by regulating translation-replication cycle through ATP-dependent and -independent mechanisms.

This study develops a yellow fever 17D reporter virus expressing thymidine kinase to enable prodrug activation and bioorthogonal labeling of infected cells for tracking viral replication and tissue tropism.

This study investigates the effects of postnatal Zika virus infection in infant macaques, finding altered neurodevelopment, increased emotional reactivity, and changes in CSF volume and brain structure.

This study identifies specific envelope protein domain III residues that determine neurovirulence and lethality of Powassan Virus lineage I, showing that mutations can attenuate the virus and elicit protective immunity.

This study evaluates the safety and insecticidal efficacy of ivermectin-treated bird feed in avian species to control West Nile virus vectors.

This study investigates NDGA's antiviral effects against WNV, finding it inhibits replication when added early post-infection and suggests involvement of SREBP and cytoskeleton pathways.

This study investigates Oropouche virus infection in human cell types and its ability to cross the blood-brain barrier, finding broad tropism and neuronal vulnerability.

Col-Ovo is an AI tool that rapidly counts Aedes aegypti eggs from smartphone images, achieving high agreement with manual counts and reducing processing time significantly.

This study identifies m6A RNA methylation as an antiviral mechanism in mosquito cells by regulating serine proteases that influence Zika virus replication.

This paper develops a mechanistic model showing that intermediate antibody levels and low CD8+ T-cell immunity increase dengue disease severity, and that CD8+ T-cell responses can mitigate antibody-dependent enhancement.

This study identifies conserved interactions of NS4B with the UFMylation pathway across orthoflaviviruses, revealing a novel role for UFMylation in viral replication and suggesting it as a therapeutic target.

This study shows that GM-CSF and M-CSF differentially regulate CHIKV infection and antiviral responses in human macrophages, with M-CSF promoting antiviral states.

This study determines the structural basis of cross-neutralization by antibody F25.S02 against Dengue and Zika viruses using cryoEM and X-ray crystallography.

This study examines the relationship between avian biodiversity and West Nile Virus (WNV) circulation in Culex mosquitoes in Emilia-Romagna, Italy, finding consistent negative associations with biodiversity indices and mixed effects based on bird species type.

This study compares the susceptibility of Old World and New World bat cell lines to Zika virus, finding that Old World bat cells support viral replication and strong inflammatory responses.