Mosquito-borne diseases and control

This study compares the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models to identify gene expression patterns associated with RNAemia and clinical symptoms.

MosAICo is an AI system for automated mosquito species identification, achieving high accuracy and out-of-distribution detection across multiple geographic regions.

biomeStat automates genomic epidemiology analysis of 1,000 Dengue virus genomes, revealing immune escape sites and conserved drug targets in under 24 hours.

This study identifies plant taxa and volatile compounds attractive to Aedes aegypti mosquitoes using DNA barcoding, behavioral assays, and volatile profiling.

This study identifies anisomycin as a potential antiviral agent against chikungunya virus, showing it inhibits viral replication and reduces disease symptoms in vitro and in vivo through a mechanism distinct from its known functions.

The paper shows that dynamic RNA structures guide viral replication by enabling conformational changes necessary for protein binding and function.

This paper uses mathematical modeling to show that avian demographic traits like breeding timing and offspring production significantly influence West Nile virus transmission dynamics in Lombardy, Italy.

This study shows that an in-frame stop codon in alphaviruses helps evade innate immune defenses in both mosquito and vertebrate hosts.

This study detects the invasive Aedes vittatus in Haiti, confirming its establishment and regional expansion, with implications for arbovirus transmission in the Americas.

This study shows that diapause in Culex pipiens involves a trade-off between somatic growth and reproductive investment, with strain-specific variation in diapause expression.

The paper identifies recombination events in dengue virus genomes using multiple methods and introduces a new tool for improved detection.

The paper uses genomic data and simulation modeling to show that Aedes aegypti populations in southern Australia can be eliminated with Wolbachia-infected male releases if rainwater tanks are removed first.

The paper reports the first detection of Usutu virus in wild birds in Scotland, identifying it as part of an expanding geographic spread rather than a new introduction.

This study evaluates the virulence and replication of 12 no-known-vector flaviviruses (NKVFVs) in mice, showing that seven are lethal in immunocompromised mice and all replicate in mouse cells.

The paper examines DENV infection in Aedes aegypti mosquito brains and finds minimal transcriptional response despite productive viral replication.

This study examines the influence of pond age and agricultural land cover on the occurrence of Anopheles maculipennis in garden ponds across Hungary using citizen science and eDNA analysis.

This study investigates Chikungunya virus assembly by combining simulations and experiments, showing that spike-spike interactions are critical for efficient budding and particle symmetry.

This paper shows that ENSO-driven temperature variability shifts dengue transmission to higher altitudes in the Andes, increasing risk for previously unaffected populations.

This study shows that AalDV2 infection increases survival of Ae. albopictus larvae at high temperatures but reduces development speed and adult size, revealing temperature-dependent trade-offs in mosquito fitness.

This study examines how urban environmental factors and microbial communities affect mosquito development and survival in larval habitats.

This study assesses the vector competence of three mosquito species in Spain for the 2024 OROV outbreak strain, finding low or no transmission potential.

This study identifies four recurrent dengue envelope protein interaction architectures using computational methods and suggests viral stability depends on local network context.

This study identifies UCHL3 as a host factor that stabilizes subgenomic flaviviral RNA condensates, promoting virus replication through interferon-independent mechanisms.

The paper examines how water availability affects West Nile virus dynamics in water-limited regions using mosquito data and panel models, finding contrasting effects on abundance and infection rates.

This study introduces structure-informed mutations in ZIKV xrRNA2 to attenuate the virus and evaluate its potential as a vaccine, finding reduced virulence and complete protection in mice.

The paper quantifies antibody cross-reactivity between Usutu and West Nile viruses in blackbirds using serological data and a Bayesian model to improve serosurveillance interpretation.

This study investigates vector distribution and diversity in Koshi Province, Nepal, finding that major vectors are present across diverse geo-ecological regions and influenced by climatic factors.

The paper develops a deep learning pipeline to identify Aedes aegypti and Aedes albopictus from citizen-science images by focusing on the scutum region, achieving improved classification accuracy.

The paper identifies JEV envelope protein mutations that may reduce vaccine effectiveness by analyzing sequence variation and structural stability.