Mosquito-borne diseases and control

This study shows that Dengue virus serotype 2 reprograms neutrophils in mice to create an immunosuppressive environment, with FGL2-expressing neutrophils playing a key role.

The paper develops spatial models to predict West Nile virus activity in Arizona using mosquito data and weather patterns, finding drought-monsoon cycles drive outbreaks and climate change will intensify them.

This study develops live-cell CHIKV reporter systems to analyze cell-type-dependent antiviral responses to ribavirin, revealing differences in antiviral efficacy across cell models.

This paper identifies SRI-38841, a xanthine analog that inhibits multiple flaviviruses by blocking NS4B-NS3 interaction and replication organelle formation.

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

This study identifies Upd as an activator of JAK/STAT signaling in mosquitoes that restricts arbovirus infection and reduces vector competence.

This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.

This paper develops a synthetic VEEV reporter virus for high-throughput antiviral screening, identifying inhibitors of VEEV replication using FDA-approved compounds.

This study shows estrogen enhances Japanese Encephalitis Virus replication in neuronal cells via the ER-PGC-1 axis and identifies it as a potential target for sex-specific therapies.

This study identifies the mitochondrial transaminase GOT2 as a metabolic dependency of JEV and a potential host-directed antiviral target through integrated transcriptomics and proteomics analyses.

This study identifies a conserved RNA tertiary motif in yellow fever virus that regulates genome cyclization through interactions with the 3'-small hairpin.

This study surveys mosquito populations in Northern Irish wetlands, identifying Culex pipiens/molestus hybrids and environmental factors influencing vector abundance.

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

This study shows that MXRA8-dependent infection of PDGFRα+ mesenchymal cells by CHIKV increases vascular permeability, enabling hematogenous spread and joint swelling.

This study tracks DENV lineage dynamics over two decades using 37,828 genomes, revealing regional diversity patterns and the impact of COVID-19 on lineage persistence and spread.

The paper investigates bacterial communities in Ae. aegypti breeding habitats and their role in oviposition behavior during arboviral outbreaks in Pune, India.

This study uses phylogeographic and phylodynamic methods to analyze DENV genome data, revealing asymmetric global spread patterns and the role of travel over climate in DENV transmission.

This study shows CHIKV infection transforms monocytes into persistently infected macrophages that drive chronic arthritis through IFN-π/IL-27-STAT1 and NF-κB pathways.

This study reports the establishment of Ae. albopictus in eastern Nebraska through long-term surveillance, showing increasing populations and evidence of overwintering.

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

This study identifies DSHS00151 as a potent inhibitor of JEV NS5-NS3 interaction, showing dose-dependent antiviral effects with IC50 values lower than CD10712.

The paper uses human iPSC-derived neurons to study WNV effects, identifying strain-specific neuroattenuation and pathogenic signatures not seen in conventional cell lines.

The paper investigates the circulation dynamics and genomic diversity of West Nile, Usutu, and Bagaza viruses in southern Portugal from 2021 to 2023, revealing contrasting patterns of viral presence and seroprevalence.

The paper develops a computational model for Zika virus sequence and secondary structure analysis using VADR, achieving high validation accuracy and extending the tool to generate structural diagrams and submit new RNA elements.

This study shows that DENV infection in mice causes gut barrier damage, bacterial translocation, and dysbiosis, which contribute to liver inflammation and disease severity.

A commercial equine vaccine against North American EEEV protects mice from MADV infection despite low or undetectable neutralizing antibody titers.

The paper identifies apoB-containing lipoproteins as a blood-borne innate immune barrier that restricts ZIKV dissemination and congenital infection risk by blocking viral entry through PS receptor competition.

The paper investigates how environmental conditions affect ecological similarity and evolutionary relatedness in mosquito communities, finding that environmental factors dominate over phylogenetic relatedness.

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.