Reproductive tract infections research

Chlamydia trachomatis outbreak: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature

The paper reports an outbreak of Chlamydia trachomatis caused by a hybrid L2b/D-Da strain with a unique genome that combines virulence features of LGV and non-LGV strains.

Medroxyprogesterone acetate mediated alteration in the vaginal microbiota and microenvironment in a Kenyan sex worker cohort

This study shows that Medroxyprogesterone Acetate (MPA) increases vaginal microbiota diversity and reduces glycogen and amylase, which correlates with increased HIV-1 susceptibility in Kenyan sex workers and humanized mice.

Antimicrobial exposure in sexual networks drives divergent evolution in modern gonococci

This study traces the evolutionary divergence of Neisseria gonorrhoeae by analyzing global isolates, linking antimicrobial use to the emergence of two distinct lineages with different resistance strategies.

Pathways-wide genetic risks in Chlamydial infections overlap between tissue tropisms: A genome-wide association scan

The paper identifies genetic pathways associated with Chlamydia trachomatis serological response and finds overlap in pathway associations between ocular and urogenital infections.

Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity

The paper analyzes Ct genomic diversity and identifies SNPs associated with ocular localization and disease severity in a West African trachoma-endemic population.

Evaluation of a Chlamydia trachomatis-specific, commercial, real-time PCR for use with ocular swabs

This paper evaluates a commercial real-time PCR assay for detecting Chlamydia trachomatis in ocular swabs, finding good sensitivity but lower specificity compared to other tests.