Reproductive tract infections research

Multi-omics uncover interactions in the vaginal microbiome and a type II secretion/Tad pilus system in Gardnerella species

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

Assessment of in vivo epithelial disruption to model anorectal Chlamydia infection in mice

This study evaluates chemical and physical epithelial disruption methods to enhance anorectal Chlamydia infection modeling in mice and tests a vaccine's efficacy in this tract.

A Pilot Study Investigating the Impact of Oral Probiotic Supplementation on the Vaginal Microbiota and Aspects of Well-being

This pilot study examines the effects of oral probiotic supplementation on vaginal microbiota and well-being in women with recurrent vaginal discomfort, finding increased detection of probiotic strains and reduced symptoms.

The Urogenital Lactobacillus Axis Across Menopause: Connections Between the Vagina, Bladder, and Urinary Metabolome

The paper examines how vaginal estrogen affects the urinary microbiome and metabolome in postmenopausal women, finding that it increases lactobacilli and alters metabolite profiles.

A Refined Developmental Transcriptomic Landscape Reveals Four Coordinated Programs in Chlamydia trachomatis

This study identifies four coordinated transcriptional programs in Chlamydia trachomatis during its developmental cycle using time-course RNA sequencing.

Mycoplasmal endosymbionts of Trichomonas vaginalis are associated with reduced risk for Chlamydia trachomatis endometrial infection in asymptomatic, coinfected, women.

Euo is Essential for Transcriptional Priming of Chlamydia trachomatis Elementary Bodies to Facilitate Secondary Infection.

Trichomonas vaginalis targets Lactobacillus jensenii via pseudopodia-independent phagocytosis and secreted lysozyme TvGH25

This study shows Trichomonas vaginalis phagocytoses Lactobacillus jensenii via pseudopodia-independent mechanism and secretes TvGH25 lysozyme to reduce bacterial counts.

Characterisation and manufacture of a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model

The paper characterizes and manufactures a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model, selecting a suitable isolate and validating a manufacturing workflow.

Ocular community state types reveal distinct microbial compositions among microbiomes with implications for trachoma control

The paper identifies ocular microbiome community state types (CSTs) in Ethiopian villagers, linking specific microbial compositions to trachoma prevalence and potential therapeutic implications.

Study of microbe-microbe interactions between the sexually transmitted parasite Trichomonas vaginalis with the cervicovaginal bacteria Lactobacillus iners

This study investigates microbe-microbe interactions between Trichomonas vaginalis and Lactobacillus iners, showing T. vaginalis engulfs L. iners and reduces its viability.

Chlamydia trachomatis deploys sphingolipids for genome organisation

This study identifies sphingolipids, specifically sphingomyelin, as key molecules involved in DNA condensation and developmental regulation in Chlamydia trachomatis.

Tracking vaginal microbiome transitions in bacterial vaginosis for cues of antibiotic resilience

The paper tracks vaginal microbiome changes in bacterial vaginosis after antibiotic treatment to identify microbial patterns linked to treatment resilience.

Fatty acid auxotrophy as driver of Lactobacillus symbiosis in the female urinary tract

This study identifies fatty acid auxotrophy as a key adaptation in Lactobacillus species of the female urinary microbiome, revealing metabolic dependencies and implications for therapeutic strategies.

An Observational Study of the Impact of Systemic B-cell Depletion on Cervicovaginal Mucosal Environment

This study examines how rituximab treatment affects vaginal mucosal immune markers, immune cell populations, and microbiome composition in women compared to healthy controls.

Characterisation of vaginal Lactobacillus isolates from South African women towards the development of a biotherapeutic to optimise the vaginal microbiome

The paper characterizes vaginal Lactobacillus isolates from South African women to identify biotherapeutic candidates that can optimize the vaginal microbiome and reduce HIV risk.

Chemotaxis and selective interactions of Trichomonas vaginalis with the vaginal bacteria

This study shows Trichomonas vaginalis exhibits chemotaxis toward Lactobacillus gasseri and avoids Gardnerella vaginalis, revealing pH taxis and selective interactions with vaginal bacteria.

Cervicovaginal Dysbiosis in HPV-Negative Women: Metagenomic Evidence Implicates Achromobacter in Female Infertility

This study identifies Achromobacter as a microbial biomarker associated with infertility in HPV-negative women through metagenomic analysis of cervicovaginal microbiota.

Genomic epidemiology of Neisseria gonorrhoeae isolates from the G-ToG clinical trial, 2014-2016

The paper analyzes whole genome sequences of Neisseria gonorrhoeae isolates from the G-ToG trial to characterize gonococcal diversity and AMR patterns in England, showing sexual network-driven phylogenetic structure and AMR differences between transmission groups.

Sialidase variability in Gardnerella: genetics, taxonomy, function, and clinical presentation

This study examines sialidase variability in Gardnerella isolates from BV-positive and negative samples, finding no clear link between taxonomy, sialidase genes, and BV status.

Divergent myelopoiesis and macrophage polarization underlie host susceptibility to chronic Chlamydia trachomatis infection

This study shows that genetic differences in mice lead to distinct myelopoiesis and macrophage polarization outcomes during Chlamydia trachomatis infection, affecting whether the infection becomes chronic.

The Vaginal Microbiome in Women Recently Experiencing BV and UTI

The paper analyzes vaginal microbiome data from 10,003 women to compare microbial signatures associated with bacterial vaginosis and urinary tract infections.

Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction

The paper shows polyamines alter G. vaginalis-induced epithelial dysfunction by changing transcriptomic profiles and inflammatory responses.

Synergistic therapeutic effects of endolysin BNT331 and a Lactobacillus crispatus consortium in a human vagina chip model of bacterial vaginosis

Endolysin BNT331 combined with Lactobacillus crispatus reduces bacterial load and suppresses inflammation in a human vagina chip model of bacterial vaginosis.

Vaginal epithelial estrogen receptor α regulates vaginal pH without detectable changes in glycogen content or microbial diversity in mice

Vitamin B2 Production by Vaginal Lactobacilli Promotes Symbiosis

This study identifies riboflavin production by vaginal lactobacilli and shows its role in modulating host immune responses and redox balance.

Clinical Candida Lactobacillus Isolate Pairs Reveal Distinct Host-Pathogen Interactions in a Vaginal Epithelial Model

The paper examines host-pathogen interactions between Candida albicans and Lactobacillus isolates in a vaginal epithelial model, showing divergent effects on cytotoxicity and pH.

Strain-level differences in Gardnerella urinary tract persistence and pathogenesis are consistent with comparative phylogenomic analyses.

This study compares Gardnerella strains in vivo to identify genomic factors associated with urinary tract persistence and pathogenesis, finding clade-specific differences in virulence and persistence.

Association Between Vaginal Community States and Preeclampsia Status in Pregnant Individuals

The paper reanalyzes 16S rRNA sequencing data to assess associations between vaginal community states and preeclampsia status, finding subtype differences in Lactobacillus spp. and reduced prevalence of D-lactic acid-producing types in preeclampsia.

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis

This study identifies a vaginal microbiome-derived antibiotic metabolite, Hydroxyisocaproate, using a systems biology approach to improve BV treatment.