Autophagy in Disease and Therapy

Patient-derived phosphoribosyl pyrophosphate synthetase mutations in Drosophila result in autophagy and lysosome dysfunction

This study shows that patient-derived PRPS mutations in Drosophila cause autophagy and lysosome dysfunction, leading to sensitivity to nutrient deprivation and oxidative stress.

Activin Signaling Regulates Autophagy and Cardiac Aging through mTORC2

This study shows activin signaling negatively regulates cardiac autophagy and health during aging in Drosophila, with mTORC2 playing a key role.

Miro ubiquitination is critical for efficient damage-induced PINK1/Parkin-mediated mitophagy

This study shows that Miro ubiquitination is essential for efficient damage-induced mitophagy, with implications for neurological diseases.

Infection dynamics in L. major autophagic machinery is regulated by ATG9-PI3P negative feedback loop

The paper investigates the role of the ATG9-PI3P negative feedback loop in regulating autophagy during Leishmania major infection.

Ratiometric assays of autophagic flux in zebrafish for analysis of familial Alzheimer’s disease-like mutations

The paper develops ratiometric assays in zebrafish to measure autophagic flux in models of familial Alzheimer’s disease mutations, finding altered flux in several genetic models.

Quantitative Assessment Of Cell Fate Decision Between Autophagy And Apoptosis

This paper builds a computational model to study how cells decide between autophagy and apoptosis under stress, revealing that cytoplasmic Ca2+ acts as a rheostat regulated by G-protein signaling and AMPK.