Autophagy in Disease and Therapy

The G protein-Coupled Metabotropic Glutamate Receptor 1 controls neuronal macroautophagy

This study identifies mGlu1 receptor's role in regulating neuronal autophagy and shows FEZ1 mediates this regulation by linking mGlu1 to Ulk1.

Modulating Intra-Nuclear LC3 with Small Molecules Rescues Cells from a Docetaxel-Induced Phenotype

The paper identifies small molecules that modulate nuclear LC3, rescuing cells from docetaxel-induced nuclear stress.

The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating mitophagy through caveolin-3

This study shows that RORα regulates mitophagy via caveolin-3 in cardiomyocytes, preserving mitochondrial function and preventing cardiac hypertrophy.

The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo

The paper shows that ATP/ADP levels and autophagy interact to regulate neuronal migration by controlling cell pausing and focal adhesion recycling in mice.

A Pan-Cancer assessment of alterations of ULK1 kinase, an upstream regulator of autophagy

The paper assesses ULK1 kinase alterations across 30+ cancer types using -omics data and structural analysis, finding downregulation in gynecological tumors and significant mutation impacts on protein stability.

Rab2 is a potent new target for enhancing autophagy in the treatment of Parkinson's disease

This paper identifies Rab2 as a target for enhancing autophagy in Parkinson's disease models, showing improved neuronal function and lifespan.

ULK1 and ULK2 are less redundant than previously thought: Computational analysis uncovers distinct regulation and functions of these autophagy induction proteins

The paper identifies distinct regulatory mechanisms and functions of ULK1 and ULK2, showing they are less redundant than previously thought.

HSC70, HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Autophagy

This study shows that EBOV-trVLPs induce autophagy via CMA, and HSC70, HSPA1A, and HSP90AB1 are required for this process.

Lipid digestion and autophagy are critical energy providers during acute glucose depletion in Saccharomyces cerevisiae

The paper identifies bulk autophagy and β-oxidation as critical energy providers during acute glucose starvation in yeast.

Stress-primed secretory autophagy drives extracellular BDNF maturation

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

Trichoplein controls endothelial cell function by regulating autophagy

This study shows that Trichoplein regulates endothelial cell function by controlling autophagy, with implications for vascular health and coronary artery disease.

Programmed Switch in The Mitochondrial Degradation Pathways During Human Retinal Ganglion Cell Differentiation from Stem Cells is Critical for RGC Survival

The paper shows that during human retinal ganglion cell differentiation, the mitochondrial degradation pathway shifts from the ubiquitine-proteasome system to the endo-lysosomal pathway, which is critical for cell survival.

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

The paper performs a quantitative systems pharmacology analysis of 225 autophagy modulators to uncover their molecular mechanisms and regulatory pathways.

Mitochondrial localization of SESN2

This study shows SESN2 localizes to mitochondria and directly regulates mitochondrial functions independently of mTORC1.

Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

This study shows that long-term synaptic depression triggers local autophagic vesicle biogenesis in dendrites, which is essential for synaptic remodeling and cognitive flexibility.

Deletion of Autophagy gene ATG1 and Glyoxylate cycle Regulator encoding gene UCC1 together leads to Synthetic Growth Defects and Sensitivity to Genotoxic agents in Saccharomyces cerevisiae

The paper investigates the genetic interaction between ATG1 and UCC1 in S. cerevisiae, showing synthetic growth defects and sensitivity to genotoxic agents.

Structural basis of p62/SQSTM1 helical filaments, their presence in p62 bodies and role in cargo recognition in the cell

This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.

Immunohistochemical Characterization of Phosphorylated Ubiquitin in the Mouse Hippocampus

The paper uses immunohistochemistry to study Ser65-pUb distribution in mouse hippocampus, finding reduced levels in PINK1-deficient mice and partial colocalization with neuronal markers.

SIPA1L2 controls trafficking and signaling of TrkB-containing amphisomes at presynaptic terminals

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

Rhes, a Striatal-Enriched Protein, Promotes Mitophagy Via Nix.

This study identifies Rhes as a striatal-enriched protein that promotes mitophagy via Nix, contributing to striatal vulnerability in the brain.

ATG13 dynamics in non-selective autophagy and mitophagy: insights from live imaging studies and mathematical modelling.

This study uses live imaging and mathematical modeling to analyze ATG13 dynamics in non-selective autophagy and mitophagy, revealing distinct patterns of translocation and their relationship to mitochondrial fragment size.

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

This study shows that WIPI2B expression counteracts age-related decline in autophagosome biogenesis in neurons, suggesting it as a therapeutic target for age-associated neurodegeneration.

AP-4 mediated ATG9A sorting underlies axonal and autophagosome biogenesis defects in a mouse model of AP-4 deficiency syndrome

This study shows that AP-4 deficiency in mice causes axonal and autophagosome biogenesis defects by impairing ATG9A sorting from the trans-Golgi network.

ULK-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn’s mutant

This study shows ULK1 phosphorylates ATG16L1, enhancing wildtype function but destabilizing the Crohn’s disease-associated mutant, thereby affecting xenophagy.

Lysosomal cystine efflux opposes mTORC1 reactivation through the TCA cycle

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.

The small non-coding vault RNA1-1 acts as a riboregulator of autophagy

This study identifies vault RNA1-1 as a riboregulator of autophagy by interacting with p62, showing that it modulates autophagic flux.

mTOR suppresses macroautophagy during postnatal development of the striatum.

The paper shows that mTOR suppresses autophagy in the striatum during postnatal development, with autophagic flux reaching adult levels by P28.

The Arabidopsis autophagy cargo receptors ATI1 and ATI2 bind to ATG8 via intrinsically disordered regions and are post-translationally modified upon ATG8 interaction

This paper investigates the molecular properties of Arabidopsis autophagy cargo receptors ATI1 and ATI2, showing their intrinsically disordered regions and post-translational modifications upon ATG8 interaction.

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.

Light induced synaptic vesicle autophagy

This study uses light-induced ROS to control SV protein damage and shows that autophagy rapidly clears damaged proteins in mouse hippocampal neurons, maintaining synaptic function.