Platelet Disorders and Treatments

This study evaluates TEG-PM for monitoring platelet transfusion efficacy in Rasgrp2-/- mice, showing K time and -angle better predict hemostatic outcomes than MA.

This paper uses multi-parameter flow cytometry and machine learning to characterize platelet sub-populations and their responses to agonists, achieving high accuracy in distinguishing platelet age and activation states.

This paper identifies a ligand that selectively binds to the A1A2 interface of von Willebrand factor under oxidizing conditions, potentially restoring auto-inhibition during inflammation.

The paper uses single-cell transcriptomics and machine learning to analyze platelet subpopulations in sepsis, COVID-19, and SLE, identifying disease-associated transcriptional signatures and potential therapeutic targets.

The paper investigates the role of clusterin in apoptosis pathways in immune thrombocytopenia (ITP) and finds increased expression of CLU and Bax in platelets and megakaryocytes.

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

The paper identifies PIK3R3 as a candidate regulator of platelet count in Bangladeshi ancestry individuals through GWAS and functional analysis.

This study uses single-cell RNA sequencing to analyze megakaryopoiesis in CD34+ cells from healthy individuals and ETV6-related thrombocytopenia patients, identifying distinct cell stages and ETV6-related defects in differentiation.

The paper shows the A1 domain is necessary for forming VWF helical tubules matching those in Weibel-Palade bodies and plays a role in intracellular assembly.

The paper examines platelet parameters in 22q11.2 deletion syndrome patients, finding that deletion status of GP1BB, not surface expression, determines platelet counts and that counts decrease with age.

This study maps in vitro megakaryocyte progenitor states to their in vivo counterparts and identifies surface markers for their purification.

This study shows that the Y14-p53 circuit is essential for megakaryocyte differentiation and platelet production, as demonstrated by mouse models and human cell experiments.

The paper identifies a rare Sardinian founder mutation in GP1BB associated with thrombocytopenia and reduced GPIb-IX-V complex expression.