Allergic Rhinitis and Sensitization

Quantitative Model of the Ocular Immune Response during Seasonal Allergic Conjunctivitis

The paper develops a mathematical model of the ocular immune response in seasonal allergic conjunctivitis, showing it captures key features of disease progression and identifies potential therapeutic targets.

Development and translational validation of a novel mouse model for allergic rhinitis

This paper develops a novel mouse model of cat allergic rhinitis that recapitulates key clinical features and enables mechanistic and therapeutic studies.

Structure-guided deimmunisation of Fel d 1 suppresses allergic effector functions ex vivo

This study designs hypoallergenic variants of Fel d 1 by disrupting IgE-binding sites, showing reduced IgE reactivity and suppressed basophil activation ex vivo.

Sensitive colorimetric ELISA measuring salivary SBP-specific secretory IgA, its application to pollinosis SLIT

This paper develops a sensitive colorimetric ELISA to measure salivary SBP-specific secretory IgA levels in patients undergoing sublingual immunotherapy for pollinosis and finds increased SIgA levels after treatment.

Effect of Shufeng Xingbi Therapy on Th1/Th2 immune balance and intestinal flora in rats with allergic rhinitis

This study evaluates the effect of Shufeng Xingbi Therapy on Th1/Th2 immune balance and intestinal flora in allergic rhinitis rats, finding improvements in inflammation and immune markers.

Ovalbumin-loaded mesoporous silica nanoparticles for allergen specific immunotherapy

This study evaluates mesoporous silica nanoparticles loaded with ovalbumin as a safer and more effective allergen-specific immunotherapy, showing protection against anaphylaxis and a Th1/Treg immune profile in mice.