A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation
Huihui Mou, Bo Gao, Gang Ye, Lizhou Zhang, Divyasha Saxena, Fan Bu, Jyoti Vishwakarma, Shuo Zhou, Claudia Ruiz Bayona, Li Lin, Yulia A. Getmanenko, Janarjan Bhandari, Charles C. Bailey, Gogce C. Crynen, Claire E. Kitzmiller, , Hyeryun Choe
This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.
Nature Communications · Oct 27, 2026Peer-reviewedMicrobiology