Structure-guided deimmunisation of Fel d 1 suppresses allergic effector functions ex vivo
Kyungsoo Ha, Soo‐Young Yum, Hyeji Kwon, Ho Won Lee, Okjae Koo, Kyeong-Hyeon Eom, Jungjoon K. Lee, Yoonjoo Choi
This study designs hypoallergenic variants of Fel d 1 by disrupting IgE-binding sites, showing reduced IgE reactivity and suppressed basophil activation ex vivo.
bioRxiv · Mar 19, 2026 · PreprintImmunology