Skin Protection and Aging

Long-Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

This paper develops a long-term human skin platform to model chronic inflammation, aging, and environmental stress, showing its utility in testing therapeutic interventions.

Human skin rejuvenation via mRNA

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Stage-specific phenotypic and transcriptional alterations in keratinocytes exposed to acute and chronic blue light

This study examines how acute and chronic blue light exposure affects human keratinocytes, finding increased proliferation, chromatin changes, and transcriptional shifts resembling malignant transformation.

UVREK: Development and analysis of an expression profile knowledgebase of biomolecules induced by ultraviolet radiation exposure

UVREK compiles manually curated data on biomolecules induced by UV radiation exposure, revealing transcription-related processes and pathways involved in cancer and aging.

A Glance into the Density of Transcriptomic Activity, Embodied by the HOX Genes, in Neonatal and Aging Dermal Cells

The paper identifies HOX gene expression changes in neonatal and aging human dermal cells, linking HOX genes to skin aging and proposing them as markers for aging assessment.

Inflammaging in human photoexposed skin: Early onset of senescence and imbalanced epidermal homeostasis across the decades.

The paper investigates inflammaging in human photoexposed skin, identifying early senescence and imbalanced epidermal homeostasis across age groups.