Skin Protection and Aging

Targeting skin ageing at the source: a novel cellular reprogramming approach using natural extract combinations

This study evaluates a novel senomorphic strategy using natural extract combinations to target RNA splicing regulation and reduce senescence in aged skin cells.

Benzopyrene induces keratinocyte senescence and p21-dependent differentiation

This study shows that benzo[a]pyrene induces keratinocyte senescence and p21-dependent differentiation, highlighting p21's role in maintaining skin barrier homeostasis under pollution exposure.

Imageomics defines granular morphological changes of human skin with age and reveals a rejuvenating effect of xenografting

The paper quantifies age-related morphological changes in human skin using imageomics and shows xenografting induces rejuvenation-like changes regardless of host age.

Characterization of a chronic UV-induced photoaging mouse model: insights into skin barrier dysfunction, extracellular matrix remodeling, and altered adipogenesis

This study characterizes a chronic UV-induced photoaging mouse model, showing reduced HA content, altered DNA repair, and increased adipogenesis over eight weeks.

Raybloc: A Marine Bioactive Silica-Microsponge Formulation Confers Superior Protection against Blue Light and Infrared-A Induced Skin Damage in Murine Model

Raybloc, a marine silica microsponge, reduces TEWL and oxidative stress in mice exposed to blue light and infrared-A radiation.

The Red Rice Bran Extract (RRBE) Mitigates Photoaging by Targeting Mitochondrial Oxidative Stress and Regulating Thermal Damage Responses

The paper develops an AI-driven platform to analyze RRBE's photoprotective mechanisms, identifying key bioactive compounds and their targets through computational and experimental validation.

A new skin supplement Purasomes XCELL: an integrative approach in regenerative aesthetics

This study evaluates the in vitro effectiveness of a new skin supplement, Purasomes XCELL, on telomere length as a marker of skin aging.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Transcriptomic and epigenetic assessment of ageing female skin and fibroblasts identifies age related reduced oxidative phosphorylation is exacerbated by smoking.

Transcriptomic and epigenetic assessment of ageing male skin identifies disruption of Ca2+ homeostasis; exacerbated by smoking and UV exposure

This study identifies age-related disruptions in calcium homeostasis in male skin fibroblasts, exacerbated by smoking and UV exposure, and links these changes to increased senescence and disease susceptibility.

Cell Senescence-Independent Ageing of Human Skin

The paper shows that while senescent cells contribute to collagen degradation with age, reduced collagen production in adult skin is due to senescence-independent processes.

Deciphering the Genome Protection Roles of Autophagy in Primary Human Dermal Fibroblasts (HDFs) against Ultraviolet(B) Induced Skin Photodamage

This study investigates how autophagy protects primary human dermal fibroblasts from UV-B induced DNA damage by regulating stress responses and DNA repair mechanisms.

Vascular Endothelial Growth Factor as an Immediate-Early Activator of UV-induced Skin Injury

This study shows that VEGF signaling is activated by UV exposure and that inhibiting it can prevent sunburn symptoms in mice, suggesting a new therapeutic approach for UV-induced skin damage.