Hormonal and reproductive studies

Beneficial early, harmful later: age-dependent effects of testicular factors on male mortality

The paper shows that castration at different ages in mice affects male mortality differently, with later castration providing greater survival benefits and suggesting age-dependent effects of testicular factors on longevity.

Molecular responsiveness to testosterone is uncoupled from skeletal muscle mass and strength in males aged 18 - 80 years

This study shows that free testosterone is linked to skeletal muscle transcriptome changes but not to muscle mass or strength in males aged 18-80.

MetAR: A semi-automated meta-analysis of skeletal muscle androgen receptors association with age

This study uses a novel R-based pipeline, MetAR, to analyze RNA-seq datasets and finds that androgen receptor expression declines with age in human skeletal muscle.