Séverine Lamon

Molecular responsiveness to testosterone is uncoupled from skeletal muscle mass and strength in males aged 18 - 80 years

This study shows that free testosterone is linked to skeletal muscle transcriptome changes but not to muscle mass or strength in males aged 18-80.

MetAR: A semi-automated meta-analysis of skeletal muscle androgen receptors association with age

This study uses a novel R-based pipeline, MetAR, to analyze RNA-seq datasets and finds that androgen receptor expression declines with age in human skeletal muscle.

Muscle mass and denervation explain variability in maximal power and rapid force across the adult female lifespan

This study examines how muscle mass and denervation affect maximal power and rapid force in adult females across their lifespan.

Development and Validation of an LC-MS Method for Quantification of Sex Steroid Hormones in Skeletal Muscle

The paper develops and validates an LC-MS method to quantify 10 sex steroid hormones in skeletal muscle tissue, achieving high sensitivity and specificity.

Tissue-specific divergence in sex-biased DNA methylation across the lifespan

This study identifies tissue-specific sex-biased DNA methylation changes across the lifespan, showing that age-related methylation changes are widespread but sex effects are rare and tissue-specific.

Mitochondria isolated from male skeletal muscle contain a distinct 1 population of miRNA that are differentially expressed following acute exercise

The paper profiles miRNA in human skeletal muscle mitochondria before and after acute exercise, finding a distinct miRNA population with hsa-miR-146b-3p differentially expressed post-exercise.

The transcriptomic signature of age and sex is not conserved in human primary myocytes

The study compares the transcriptomic profiles of human muscle biopsies and their derived primary myocytes, finding minimal retention of age and sex-related gene expression patterns in culture.

DNA Methylation Ageing Atlas Across 17 Human Tissues

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

Skeletal muscle mitochondria contain nuclear-encoded RNA species prior to and following adaptation to exercise training in rats

This study identifies nuclear-encoded RNAs in mitochondria of rat skeletal muscle, with some miRNAs showing altered abundance after exercise training.

The effect of age and sex hormones on female neuromuscular function across the adult lifespan

This study examines how age and sex hormones affect female neuromuscular function across adulthood, finding accelerated decline around menopause linked to hormonal changes and muscle vulnerability.

Total testosterone is not associated with muscle mass, function or exercise adaptations in pre-menopausal females

This study finds that total testosterone is not linked to muscle mass or strength in pre-menopausal females, but bioavailable testosterone and nuclear-localized androgen receptor are associated with muscle hypertrophy.

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

Direction-aware functional class scoring enrichment analysis of Infinium DNA methylation data

The paper introduces a directional functional class scoring method for Infinium DNA methylation data, showing improved performance in detecting pathway methylation differences in various biological contexts.

The interactive effect of sustained sleep restriction and resistance exercise on skeletal muscle transcriptomics in young females

This study examines how sleep restriction and resistance exercise interact to affect skeletal muscle transcriptomics in young females, finding that sleep loss moderates the gene expression response to exercise.

ACTN3 genotype influences androgen response in skeletal muscle

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

Primary human myoblasts display only minor alternative polyadenylation compared to the transformed C2C12 model of muscle differentiation

The paper compares alternative polyadenylation in primary human myoblasts and C2C12 cells during differentiation, finding less alternative polyadenylation in human cells.

Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

The paper integrates skeletal muscle methylome and transcriptome data across three cohorts to identify sex differences in DNA methylation and gene expression, revealing functional links between epigenetic and transcriptional sex biases.