Shangang Zhao

Transferrin receptor binding valency determines the circulating half-life and weight-loss efficacy of Fc-FGF21 in TfR-humanized mice

This study shows that Fc-FGF21's weight-loss efficacy depends on its circulating half-life, which is influenced by hTfR binding valency and BBB transport.

Beneficial early, harmful later: age-dependent effects of testicular factors on male mortality

The paper shows that castration at different ages in mice affects male mortality differently, with later castration providing greater survival benefits and suggesting age-dependent effects of testicular factors on longevity.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis

This paper investigates 4-Methylumbelliferone's potential as a repurposed treatment for liver fibrosis, finding that it lacks efficacy at translatable doses and has an unclear mechanism.

Microglial cGAS deletion protects against amyloid-β induced Alzheimer's disease pathogenesis

This study shows that deleting cGAS in microglia reduces amyloid-β plaque formation and cognitive impairment in Alzheimer's disease models.