Parasitic infections in humans and animals

Inhibition of Hippo signalling disrupts germinative cell-cycle progression and larval development in Echinococcus multilocularis

This study investigates the Hippo signaling pathway in Echinococcus multilocularis, showing that inhibiting Hippo signaling disrupts germinative cell-cycle progression and larval development.

Shared landscapes, shared risk: Echinococcus multilocularis infection in coyotes is linked to agricultural land and altered green space in a major U.S. metropolitan area

The paper examines Echinococcus multilocularis infection in coyotes in Chicago, finding higher infection rates in areas with agricultural land and altered green spaces, linked to human activity and zoonotic risk.

Persistence of regenerative stem cells provides a cellular basis for the parasitostatic activity of albendazole against Echinococcus multilocularis

This study shows that albendazole targets Echinococcus multilocularis metacestode tissue but spares regenerative stem cells that can regenerate the parasite after drug withdrawal.

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

This study evaluates the effects of ion-channel and cytoskeletal modulators on Echinococcus granulosus protoscoleces, finding concentration-dependent motility reduction and distinct effects on viability and structure.

A single-cell transcriptomic atlas of the Echinococcus multilocularis metacestode reveals cellular diversity and molecular specialization

This study creates a single-cell transcriptomic atlas of Echinococcus multilocularis metacestodes, identifying 26 cell populations and revealing molecular specialization and heterogeneity.

Pericystic brain transcriptomics reveals molecular signatures of immune activation and neurovascular remodelling in viable and post-treatment porcine neurocysticercosis

This study uses bulk RNA sequencing in a porcine model of neurocysticercosis to identify transcriptional signatures associated with viable parasite persistence and post-treatment lesion disruption.

Effects of Llama-Derived Hyperimmune Serum on Motility and Viability of Echinococcus granulosus Protoscoleces

This study evaluates hyperimmune serum from llamas immunized against Echinococcus granulosus protoscoleces, showing dose-dependent inhibition of motility and viability.

Repurposing Niclosamide Ethanolamine for Alveolar Echinococcosis Reveals a Disconnect Between In Vitro Efficacy and In Vivo Outcome

This study tests niclosamide ethanolamine (NEN) as a treatment for alveolar echinococcosis, finding strong in vitro efficacy but no significant in vivo effect in mice.

Triclabendazole inhibits succinate dehydrogenase in vitro

This study shows triclabendazole and its metabolites inhibit SDH in cestode, helminth, and mammalian mitochondria, suggesting shared mechanism and potential mammalian safety risks.

On the possible inhibition of macrophage inflammatory responses by phytic acid produced by Echinococcus multilocularis

The paper investigates how phytic acid from Echinococcus multilocularis affects macrophage inflammatory responses and challenges the role of calcium depletion in this inhibition.

Detection of Echinococcus multilocularis in coyotes in Washington State, USA highlights need for increased global wildlife surveillance

This study detects Echinococcus multilocularis in coyotes in Washington State, USA, revealing its geographic expansion and highlighting the need for improved surveillance.

scRNA + TCR + BCR-seq Reveals the proportion and characteristics of dual TCR T cells and dual BCR B cells in mice infected with Echinococcus granulosus

The paper uses scRNA+TCR+BCR-seq to analyze immune cell responses in mice infected with Echinococcus granulosus, identifying dual receptor T and B cells with distinct characteristics and potential roles in immune regulation.

Genetic heterogeneity in Taenia solium cysticerci among naturally infected pigs revealed by microsatellite markers and associated epidemiological risk factors.

The paper examines genetic diversity in Taenia solium cysticerci in pigs using microsatellite markers and identifies epidemiological risk factors associated with infection.

The effects of E. granulosus PSCs proteins on host immune cells were elucidated through Transcriptomic and Metabolomic analyses

This study investigates how E. granulosus PSCs affect host immune cells through transcriptomic and metabolomic analyses, revealing immune metabolic reprogramming and cytokine regulation.

Anthelminthic Activity of the Aqueous Extracts of Moringa oleifera Leaf Against Taenia solium Cysticerci

This study evaluates the anthelmintic activity of Moringa oleifera leaf extracts against Taenia solium cysticerci, showing moderate inhibition of evagination compared to Praziquantel.

From cyst to tapeworm: Transcriptome of Taenia solium in vitro activation and growth

This study presents a transcriptome of Taenia solium cysts at different in vitro growth phases to identify genes and processes involved in their activation and development into adult worms.

Prevalence of Bovine Cysticercosis, Human Taeniasis and Associated Risk Factors in Selected Towns of Silte Zone, Southern Ethiopia

Molecular characterization of a DyP-type peroxidase from the human parasitic cestode Echinococcus multilocularis

The paper characterizes EmDyp, a Dyp-type peroxidase from Echinococcus multilocularis, showing its enzymatic activity and expression patterns, suggesting a role in ROS defense and potential as a therapeutic target.

Assembly and phylogeographic analysis of novel Taenia solium mitochondrial genomes reveal further differentiation between and within Asian and African-American genotypes

The paper assembles and analyzes mitochondrial genomes of Taenia solium from Latin America, identifying SNPs and phylogeographic patterns that suggest metabolic differences and historical spread of the parasite.

The susceptibility analysis of Echinococcus multilocularis protoscoleces tubulin to mebendazole and RNA interference

This study evaluates mebendazole and RNA interference effects on E. multilocularis protoscoleces tubulin, showing mebendazole suppresses tubulin expression and alters morphology, while RNA interference targets β2 tubulin in the protonephridial system.

The secreted protein signature of hydatid fluid from pulmonary cystic echinococcosis

The paper identifies and compares the protein content of hydatid fluid from Echinococcus granulosus and Echinococcus ortleppi to understand their molecular strategies for survival in the host.

Comparative Transcriptomes Analysis of Taenia pisiformis at Different Development Stages

This study analyzes the transcriptomes of Taenia pisiformis at larval and adult stages to identify differentially expressed genes, providing insights for vaccine antigen and drug target screening.

Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses

The paper integrates DNA methylation and transcriptomic data from Cysticercus cellulosae to show DNA methylation regulates key parasitism genes.

Development of real-time polymerase chain reaction assays allowing molecular detection of Echinococcus felidis, Echinococcus granulosus sensu stricto, and Echinococcus canadensis in carnivore feces samples, animal and human hydatid cyst material from Uganda and Kenya

The paper develops and validates real-time PCR assays for detecting three Echinococcus species in field samples from Uganda and Kenya.

Taenia solium TAF6 and TAF9 binds to a putative Downstream Promoter Element present in TsTBP1 gene core promoter

The paper characterizes the TsTBP1 gene in Taenia solium, identifies a TATA-less promoter with a DPE bound by TAF6 and TAF9, and proposes consensus sequences for promoter elements in the Taeniidae family.