Orthopedic Infections and Treatments

Quantification of bone loss, periosteal bone formation and novel histopathological changes in a mouse implant-related Staphylococcus aureus infection model

This study quantifies bone loss and histopathological changes in a mouse implant infection model, showing host-driven bone remodeling and correlations with bacterial:host genome ratios.

Culture Positivity Reflects Quantitative Bacterial Bioburden in Open Fractures

This study shows that culture positivity in open fractures correlates with higher bacterial bioburden, suggesting microbial load rather than specific pathogens drives infection risk.

Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical Outcome

The paper identifies immune checkpoint proteins as biomarkers for predicting adverse outcomes in Staphylococcus aureus bone infections using a humanized mouse model and clinical data.

SmartSpacer: Design, Implementation, and In-Vitro Validation of a Multimodal Sensorized Knee Spacer for Continuous Infection Monitoring in Two-Stage Revision Arthroplasty

The paper introduces SmartSpacer, a sensorized knee spacer for continuous infection monitoring in two-stage revision arthroplasty, validated through in vitro experiments demonstrating reliable performance and extended battery life.

Towards In Vivo Wearable Diagnostics in Orthopaedics: Sensorized Bone Cement for Knee Spacer Applications

This paper develops a sensorized bone cement for knee spacers to enable continuous in vivo monitoring of infection resolution in orthopedic implants.

Utility of Kirschner Wires as Prosthetic Implants to Investigate Establishment and Treatment of Biofilm Associated Infections in a Galleria mellonella Model

This study evaluates the effectiveness of phage and antibiotic treatments against S. aureus biofilms on Kirschner wires in a Galleria mellonella model, finding improved survival with vancomycin alone or combined with phage.

The metallophore staphylopine is essential for survival of Staphylococcus epidermidis in human synovial fluid

This study identifies staphylopine as essential for Staphylococcus epidermidis survival in human synovial fluid using transposon mutagenesis and RNAseq.

A Novel Approach to Reducing Spinal Implant-Associated Infections

This study shows that ultrafine-grained stainless steel implants reduce early Staphylococcus aureus biofilm formation in vitro and in mouse models.

Staphylococcus aureus adopts revertible intracellular viable-but-non-culturable phenotypes in chronic osteocyte infections

This study shows Staphylococcus aureus can enter a viable-but-non-culturable state within osteocytes, escape, and revert to active growth, explaining culture-negative but PCR-positive osteomyelitis.

Investigating the translational value of Periprosthetic Joint Infection (PJI) models to determine the risk and severity of Staphylococcal biofilms.

This study evaluates preclinical models to assess the risk and severity of Staphylococcal biofilms in periprosthetic joint infections and their antibiotic susceptibility.

Influence of residual microbial nucleic acid in instruments for hip joint arthroplasty on false-positive results of metagenomic sequencing

The paper analyzes how residual microbial nucleic acid in hip arthroplasty instruments affects false-positive results in metagenomic sequencing across different hospitals.