Gastrointestinal Tumor Research and Treatment

B7-H4 represents a site-specific immunotherapy target in small bowel gastrointestinal stromal tumor

This study identifies B7-H4 as a site-specific immunotherapy target in small bowel GISTs, showing its upregulation and association with an immunosuppressive tumor microenvironment.

dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors

dbGIST is a multi-omics resource for GIST research that integrates diverse datasets and provides analytical tools for target exploration and cross-dataset validation.

Quantifying Treatment Resistance in Mixtures of Gastrointestinal Stromal Tumor Cells with BARMIX

BARMIX quantifies treatment resistance in gastrointestinal stromal tumor cell mixtures using barcoded experiments and probabilistic modeling, accurately reflecting clinical resistance patterns.

MITF Targets in Gastrointestinal Stromal Tumors: Implication in Autophagy and Extracellular Vesicle Secretion

This study identifies MITF-regulated genes in GIST, showing its role in autophagy and extracellular vesicle secretion, with implications for tumor growth and metastasis.

Systematic elucidation and pharmacologic targeting of non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumor

This study identifies non-oncogene dependencies in imatinib-resistant GIST using network-based methods and validates six drugs that reverse MR activity in preclinical models.

Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes

The paper identifies six molecular subtypes of GIST using single nucleus RNA sequencing and correlates them with clinicopathologic features and clinical outcomes.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Liquid biopsy in gastrointestinal stromal tumors -- Simultaneous detection of primary and secondary mutations with an NGS based circulating tumor DNA assay