HIV-related health complications and treatments

Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction

This study identifies metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction using proteomics and MRI.

The anti-retroviral therapy emtricitabine affects skeletal muscle DNA methylation and transcriptome patterns in a male HIV mouse model

This study examines how emtricitabine, an antiretroviral drug, alters DNA methylation and transcriptome patterns in skeletal muscle of HIV-infected mice, revealing potential mechanisms of ART-related muscle dysfunction.

Alterations in Circulating T-Cell Subsets with Gut-Homing/Residency Phenotypes Predict HIV-1 Status and Subclinical Atherosclerosis

The paper identifies specific T-cell subsets with gut-homing/residency markers that predict HIV status and subclinical atherosclerosis in ART-treated individuals.

Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa

The paper identifies inflammation-related proteins associated with age, sex, and CD4+ cell count in HIV-positive individuals in South Africa, highlighting potential links to chronic diseases.

Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

The paper identifies three metabolic at-risk profiles in HIV-treated patients using multi-omics integration, highlighting dysregulated metabolism and microbiome interactions.

SiZer Map to investigate significant features of body-weight profile changes in HIV infected patients in the IeDEA Collaboration

The paper introduces PS-SiZer, a method for analyzing longitudinal biomarker data, and applies it to study weight gain durability in HIV patients on different ART regimens.