The paper links ALDH activity in monocytes to subclinical coronary atherosclerosis in HIV-1 treated individuals, independent of traditional risk factors.

bioRxiv · Aug 25, 2026 · PreprintImmunology

Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1

Étienne Bélanger, Alexandra Tauzin, Fitsumbrhan Tajebe, Monika Chandravanshi, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Catherine Bourassa, Halima Medjahed, William David Tolbert, Madéleine Durand, Jonathan Richard, Donna M. Huryn, Simona Stäger, Marzena Pazgier, Andrés Finzi

This study shows that HIV-1 infected cells with open Env conformations are vulnerable to ADCP mediated by PWH plasma, and that Nef and Vpu protect against this by preventing premature Env opening.

mBio · Jul 29, 2026Peer-reviewedMicrobiology

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients

Haley E. Randolph, Raúl Aguirre‐Gamboa, Elsa Brunet‐Ratnasingham, Tomoko Nakanishi, Zepeng Mu, Veronica Locher, Ellen Ketter, Cary Brandolino, Catherine Larochelle, Alexandre Prat, Nathalie Arbour, Anne Dumaine, Andrés Finzi, Madéleine Durand, John Brent Richards, , Luis Bruno Barreiro

This study identifies gene-environment interactions influencing immune response to SARS-CoV-2 in hospitalized patients using single-cell RNA-sequencing and eQTL analysis.

Nature Communications · Apr 28, 2026Peer-reviewedGenomics

Alterations in Circulating T-Cell Subsets with Gut-Homing/Residency Phenotypes Predict HIV-1 Status and Subclinical Atherosclerosis

Etiene Moreira Gabriel, Jonathan Dias, Abdelali Filali-Mouhim, Ramon Edwin Caballero, Tomas Raul Wiche Salinas, Manon Nayrac, Carl Chartrand‐Lefebvre, Jean‐Pierre Routy, Madéleine Durand, Mohamed El Far, Cecile L. Tremblay, Petronela Ancuța

The paper identifies specific T-cell subsets with gut-homing/residency markers that predict HIV status and subclinical atherosclerosis in ART-treated individuals.

Cells · Nov 4, 2025Peer-reviewedImmunology

Genome-wide Association Study of Long COVID

Vilma Lammi, Tomoko Nakanishi, Samuel E. Jones, Shea J. Andrews, Juha M Karjalainen, Beatriz Cortés, Heath O’Brien, Ana Ochoa-Guzmán, Brian Fulton‐Howard, Martin E. Broberg, Hele Haapaniemi, Masahiro Kanai, Matti Pirinen, Axel Schmidt, Ruth E. Mitchell, , Sergi Papiol

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

Nature Genetics · May 21, 2025Peer-reviewedGenetic & Genomic Medicine

A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

Sirui Zhou, Guillaume Butler‐Laporte, Tomoko Nakanishi, David Morrison, Jonathan Afilalo, Marc Afilalo, Laetitia Laurent, Maik Pietzner, Nicola D. Kerrison, Kaiqiong Zhao, Elsa Brunet‐Ratnasingham, Danielle Henry, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, , John Brent Richards

This study identifies OAS1 as a protective factor against COVID-19 severity and susceptibility using Mendelian randomization and case-control analyses.

Nature Medicine · Feb 25, 2021Peer-reviewedGenetic & Genomic Medicine