Zebrafish Biomedical Research Applications

The paper uses live-cell imaging to study neural network development in zebrafish, revealing conserved structural dynamics and optimization strategies.

This study uses fluorescent protein knock-in lines in zebrafish to track Collagen4 remodeling in cardiovascular development and regeneration.

Zebrafish larva infection experiments plus pharmacokinetic-pharmacodynamic (PKPD) modelling gave bedaquiline's in vivo Emax and EC50 against M. marinum in about 2 months; waterborne clarithromycin barely entered larvae.

The paper develops a multiplex CRISPR-Cas9 gRNA toolkit to generate fully unpigmented zebrafish larvae with minimal mortality, enabling improved imaging without chemical inhibitors.

This study quantifies spatial asymmetry in zebrafish pectoral fin regeneration, revealing differential gene expression and signaling dynamics between anterior and posterior regions.

The paper introduces an open-source VR platform for head-fixed adult zebrafish to study behavior and neuronal activity in controlled virtual environments.

gene2fish arranges 53,595 Thisse in situ hybridization images of 8,263 zebrafish genes into a gene-by-stage grid, with anatomy-term search for validating scRNA-seq markers.

This study optimizes breeding conditions for Danionella cerebrum to enhance egg production and collection efficiency.

This study shows laminin and fibronectin guide endothelial self-organization during intersegmental vessel formation in zebrafish by constraining network-forming behavior.

This paper develops a motor endurance assay for zebrafish larvae to study neurological diseases, finding reduced endurance in TDP43-overexpressing larvae and MPP+-treated larvae.