Rainer W. Friedrich

Open-source virtual reality platform for head-fixed adult zebrafish

The paper introduces an open-source VR platform for head-fixed adult zebrafish to study behavior and neuronal activity in controlled virtual environments.

Fine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulb

The paper reveals the fine ultrastructural organization of protoglomeruli in the developing zebrafish olfactory bulb, showing their subdivision into microglomeruli with distinct mitral cell arrangements.

Representational learning by optimization of neural manifolds in an olfactory memory network

The paper analyzes how olfactory memory in zebrafish is represented through neural manifolds, finding that training enhances the separation of task-relevant odor representations.

Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex

This study shows that zebrafish pDp represents odor and temporal information together, with experience improving how well this information is organized and generalized.

Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

The paper classifies neuron types and their connectivity in the zebrafish olfactory bulb using ultrastructural features from electron microscopy.

Dynamic cognitive representations in the dorsal pallium of adult zebrafish

The paper investigates spatial representations in the dorsal pallium of adult zebrafish, showing neurons encode environmental space with landmark associations and internal predictive models.

Odor preference maps to cohesive transcriptional domains in the olfactory bulb

The paper identifies transcriptional domains in the zebrafish olfactory bulb that correlate with odor preference and shows specific neuronal subtypes are recruited based on odor preference.

A deep learning framework for automated and generalized synaptic event analysis

This paper introduces miniML, a deep learning framework for automated synaptic event detection that outperforms existing methods in precision and recall across diverse preparations and species.

Computational functions of precisely balanced neuronal assemblies in an olfactory memory network

The paper investigates the computational role of balanced excitatory-inhibitory neuronal assemblies in zebrafish olfactory memory networks, showing they prevent runaway activity and correlations.

Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex

The paper builds a spiking network model of zebrafish olfactory cortex to study how E/I assemblies affect memory representation, finding continuous representations that enable fast classification and continual learning.

Molecular logic of neuromodulatory systems in the zebrafish telencephalon

The paper maps neuromodulatory systems in zebrafish telencephalon using transcriptomics, revealing cell type-specific GPCRs and neuropeptide combinations.

The structure and function of neural connectomes are shaped by a small number of design principles

The paper develops probabilistic generative models for neural connectomes across species, showing that simple design principles can accurately replicate structural and functional properties.

A viral toolbox for conditional and transneuronal gene expression in zebrafish

The paper develops viral tools for conditional and transneuronal gene expression in zebrafish to study neuronal circuits.

Database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging data

The paper introduces a database and deep learning tool for spike inference from calcium imaging data, outperforming existing methods with an automated, parameter-free algorithm.

Whitening of odor representations by the wiring diagram of the olfactory bulb

The paper shows that the olfactory bulb's wiring diagram enables odor representation whitening by suppressing redundant responses through reciprocal inhibition.

Predictive neural processing in adult zebrafish depends on shank3b

This study shows that predictive processing in adult zebrafish depends on the shank3b gene, with altered error signals in specific forebrain regions.

Rapid olfactory discrimination learning in adult zebrafish

This study develops an automated odor discrimination task for adult zebrafish, showing they can rapidly learn fine odor discriminations through conditioned feeding behavior.