Microbial infections and disease research

Host transcriptional programs underlying lesion development in contagious bovine pleuropneumonia

This study identifies host transcriptional changes during different stages of Mmm infection in cattle, revealing immune and tissue remodeling pathways involved in lesion progression.

An atypical F-type ATPase is necessary for the function of the antibody cleavage system MIB-MIP in mycoplasmas.

The paper shows that an atypical F-type ATPase is required for the MIB-MIP system's function in mycoplasmas to evade immune agglutination.

Host prior exposure augments heterogeneity in gene expression in both host and pathogen during in vivo infection

This study shows prior pathogen exposure increases gene expression heterogeneity in both host and pathogen during reinfection in house finches.

Transport stress induces paradoxical increases in airway inflammatory responses in beef stocker cattle

This study shows that transport stress in beef stocker cattle increases lung inflammation without pathogen exposure, suggesting a paradoxical immune response.

Multi-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children

This study identifies severity signatures in Mycoplasma pneumoniae infection using multi-omics and machine learning, revealing key biomarkers and pathways associated with severe disease in children.

Paying upfront: successful initial infections protect against severe future infections

The study shows that successful initial infections in house finches protect against severe future infections, with males being more susceptible than females.

Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice

This study identifies genes essential for two P. multocida strains to survive in mice, revealing differential requirements for systemic infection despite shared growth genes.

Antimicrobial Susceptibility and Genomic Determinants of Resistance and Virulence in Mycoplasma cynos and Mycoplasma felis

This study evaluates antimicrobial susceptibility and identifies genetic markers of resistance and virulence in Mycoplasma cynos and Mycoplasma felis using genomic and phenotypic analyses.

Identification of genes that differentiate Mannheimia haemolytica genotypes 1 and 2 using a pangenome approach

This study identifies 422 genes differentiating Mannheimia haemolytica genotypes 1 and 2 using a pangenome approach, focusing on virulence and fitness-related genes.

Bacterial Conjugation in the Ruminant Pathogen Mycoplasma agalactiae is Influenced by Eukaryotic Host Factors

This study shows that Mycoplasma agalactiae conjugation increases in co-culture with eukaryotic cells, leading to genetic exchange and mosaic genomes, with nucleotide stress potentially modulating this process.

Porcine Nasal Organoids as a model to study the interactions between the swine nasal microbiota and the host

This paper develops porcine nasal organoids to study host-microbe interactions in respiratory infections and shows that Rothia nasimurium inhibits inflammation from other bacteria.

Mycoplasma gallisepticum (MG) infection inhibits mitochondrial respiratory function in a wild songbird

This study examines how Mycoplasma gallisepticum infection affects mitochondrial respiration in house finches, finding reduced respiration rates at different stages of infection.

Fusobacterium necrophorum and Fusobacterium varium are commensal members of the bovine reproductive microbiota and may colonize calf prenatally

The paper identifies Fusobacterium species as commensal members of the bovine reproductive microbiota and shows their presence in calf prenatal samples.

Antimicrobial Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease

This study analyzes antimicrobial resistance and virulence genes in Pasteurella multocida and Mannheimia haemolytica from Polish dairy calves with bovine respiratory disease, finding high resistance to tetracyclines and penicillin, and susceptibility to fluoroquinolones.

The T-type voltage-gated Ca2+ channel CaV3.1 as a candidate receptor for Pasteurella multocida toxin and contributes to the disruption of respiratory epithelial barrier induced by the toxin

This study identifies CaV3.1 as a receptor for PMT that disrupts respiratory epithelial barriers by inducing Ca2+ influx and signaling pathways.

A high lipid diet leads to greater pathology and lower tolerance during infection

This study shows that a high lipid diet increases pathology and reduces tolerance in canaries infected with Mycoplasma gallisepticum compared to a high protein diet.

Genomic and metabolic characterization of Trueperella pyogenes isolated from domestic and wild animals

This study characterizes the genomic and metabolic features of Trueperella pyogenes from various animal hosts, identifying its non-host-specific nature and antimicrobial resistance genes.

Biofilm formation in Streptococcus suis: In vitro impact of serovar and assessment of coinfections with other porcine respiratory disease complex bacterial pathogens.

This study evaluates biofilm formation in S. suis isolates and coinfections with PRDC pathogens, finding serovar-specific differences and enhanced biofilm in mixed cultures with P. multocida.

TbpB-based oral mucosal vaccine provides heterologous protection against Glasser disease caused by different serovars of Spanish field isolates of Glaesserella parasuis

This study shows an oral mucosal TbpB-based vaccine protects piglets against multiple G. parasuis serovars by reducing bacterial colonization and improving survival.

Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice

This study shows that C57BL/6J, BALB/cJ, and J:ARC(S) mice develop persistent subclinical Chlamydia muridarum infections with immune responses, suggesting the need to exclude Cm from mouse colonies used in GI disease research.

Pangenomic analysis of Helcococcus ovis reveals widespread tetracycline resistance and a novel bacterial species, Helcococcus bovis.

This study identifies a novel Helcococcus species, H. bovis, and reveals widespread tetracycline resistance and convergent gene loss in H. ovis isolates from dairy cows.

Comparative genomic analysis identifies potential adaptive variation and virulence factors in Mycoplasma ovipneumoniae

This study compares M. ovipneumoniae genomes from six countries and four host species, identifying adaptive variation and virulence factors linked to carbon metabolism and host-specific evolution.

A detailed analysis of 16S rRNA gene sequencing and conventional PCR-based testing for the diagnosis of bacterial pathogens and discovery of novel bacteria

This study compares 16S rRNA gene sequencing and conventional PCR for diagnosing bacterial pathogens in chickens with swollen head syndrome, finding that sequencing is more reliable and can detect novel bacteria.

Genomic characterisation of a novel species of Erysipelothrix associated with mortalities among endangered seabirds

The paper genomes 16 Erysipelothrix isolates from albatross carcasses, identifies them as a novel species, and proposes the name Erysipelothrix amsterdamensis.

Hematological and gene co-expression network analyses of high-risk beef cattle defines immunological mechanisms and biological complexes involved in bovine respiratory disease and weight gain

This paper uses gene co-expression networks and hematological data to identify gene modules and hub genes associated with BRD development and weight gain in cattle.

A Trifector of New Insights into Ovine Footrot for Infection Drivers, Immune Response and Host Pathogen Interactions

This paper analyzes the bacterial and host transcriptomes in ovine footrot to identify infection drivers, immune responses, and host-pathogen interactions in a natural polymicrobial infection.