P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

Science · Sep 24, 2026Peer-reviewedCancer Biology✦ In-depth digest

Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice

Noah Mishkin, Sebastian E. Carrasco, Michael B Palillo, Panagiota Momtsios, Cheryl L Woods, Kenneth S Henderson, Ana Leda F. Longhini, Chelsea Otis, Rui Gardner, Ann Mary Joseph, Gregory F. Sonnenberg, Jack A Palillo, Rodolfo J Ricart Arbona, Neil S Lipman

This study shows that C57BL/6J, BALB/cJ, and J:ARC(S) mice develop persistent subclinical Chlamydia muridarum infections with immune responses, suggesting the need to exclude Cm from mouse colonies used in GI disease research.

Comparative Medicine · Nov 19, 2024Peer-reviewedMicrobiology

Charting the emergent organotypic landscape of the mammalian gut endoderm at single-cell resolution

Sonja Nowotschin, Manu N. Setty, Ying-Yi Kuo, Vincent Chi Hang Lui, Vidur Garg, Roshan Sharma, Claire S. Simon, Néstor Saiz, Rui Gardner, Stéphane C. Boutet, Deanna M. Church, Pamela A. Hoodless, Anna‐Katerina Hadjantonakis, Dana Pe’er

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.

bioRxiv · Nov 15, 2018 · PreprintDevelopmental Biology