Autoimmune Bullous Skin Diseases

Network Toxicology, Molecular Docking, and Molecular Dynamics Simulations Reveal the Mechanism of Tetrabromobisphenol A in Bullous Pemphigoid.

This study identifies molecular mechanisms by which TBBPA contributes to BP pathogenesis using network toxicology, molecular docking, and MD simulations, revealing key targets and interactions.

A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease

This study develops a human immune system mouse model for EBA, demonstrating that PDK1 inhibition reduces skin inflammation and immune cell activation.

Gut Microbiota Modulates and Predicts Disease Severity in Experimental Pemphigoid Disease

This study shows gut microbiota influences disease severity in an experimental pemphigoid model, with specific taxa linked to protection or inflammation.

In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes

The paper shows that in pemphigus, cell detachment, not autoantibody binding, causes long-term transcriptomic and proteomic changes associated with blister formation.