Boron Compounds in Chemistry

The First Experience of Accelerator-based Lithium Neutron Capture Therapy in vivo

This study demonstrates lithium neutron capture therapy (LiNCT) in mice, showing improved tumor growth inhibition and survival compared to boron-based BNCT.

Universal nucleic acid preservation in biological fluids with boron clusters

This paper introduces [B12H12]2- as a broad-spectrum nuclease inhibitor that preserves nucleic acids in biological fluids at room temperature for extended periods.

Bone marrow-derived macrophages loaded with boron carbide nanoparticles as selective boron carriers for crossing the blood-brain barrier toward the glioma microenvironment for boron neutron capture therapy

This paper demonstrates that bone marrow-derived macrophages loaded with boron carbide nanoparticles can effectively deliver boron-10 across the blood-brain barrier to glioma cells, showing potential for boron neutron capture therapy.

L-Phenylalanine restriction amplifies boron neutron capture therapy efficacy through increased L-boronophenylalanine uptake and induces activating transcription factor 4 stress response in tumor cell lines

This study shows that restricting L-phenylalanine increases BPA uptake in tumor cells, enhancing BNCT efficacy and inducing ATF4 stress response through LAT1/4F2HC-mediated transport.

Carborane-NHS esters as versatile reagents for amine-selective small-molecule modification, bioconjugation, and peptide-polymer assembly

This paper develops carborane-NHS ester reagents for selective amine modification of biomolecules, demonstrating their use in conjugating antibodies with carboranes for boron neutron capture therapy.

EGFR-targeted antisense oligonucleotides modified with boron clusters offer an innovative approach to cancer chemo-radiotherapy

This paper demonstrates that B-ASOLNA-CHOL, a boron cluster-conjugated antisense oligonucleotide, enhances cancer cell uptake and cytotoxicity when combined with radiotherapy, reducing tumor size in xenograft models.

Boosting Antitumour Efficacy and Immunity by Boron Neutron Capture Therapy with Size-Controlled Nanoparticles

This paper develops size-controlled boron-10 carbide nanoparticles for BNCT, showing improved tumour selectivity, reduced dosage, and enhanced antitumour immunity with minimal side effects.

Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model

The paper investigates the cytotoxic effects of transition metal metallacarboranes on triple-negative breast cancer cells and a vertebrate model, showing significant toxicity at nanomolar concentrations.