Glutathione Transferases and Polymorphisms

Absence of Glutathione S-Transferase Theta 1 Gene is Significantly Associated with Breast Cancer Susceptibility in Pakistani Population and Poor Overall Survival in Breast Cancer Patients: A Case-Control and Case Series Analysis

This study finds that the GSTT1-absent genotype is significantly associated with increased breast cancer risk and poorer overall survival in Pakistani patients.

The soluble glutathione transferase superfamily: Role of Mu class in Triclabendazole sulphoxide challenge in Fasciola hepatica

This study investigates the response of the soluble GST superfamily in Fasciola hepatica to TCBZ-SO exposure, identifying specific GST isoforms involved in detoxification.

Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex

This study identifies Gstp proteins' role in neurite initiation and elongation during cortical development, showing their regulation through JNK signaling.

GSTM1 copy number is not associated with risk of kidney failure in a large cohort

This study investigates the association between GSTM1 copy number and kidney failure risk in a large cohort, finding no significant association after adjustments.

Complex haplotypes of metabolizing GSTM1 gene deletion harbors signatures of a selective sweep in East Asian populations

The paper investigates the evolutionary history of the GSTM1 gene deletion in East Asian populations, finding evidence of a soft sweep and its association with disease susceptibility.