Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
Fractal and DNA sequence analysis
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
55 papers
UniWave-2: A Hybrid Model for Nucleic Acid Waveform Feature Extraction Enhanced by Fourier and Wavelet Transforms
Hao Zhang, Yujun Qi, Yulan Feng, Lili Wang
UniWave-2 improves nucleic acid sequence analysis by integrating hydrophobicity, enhancing waveform resolution with Fourier and wavelet transforms, and using a lightweight GRU model for efficient feature extraction.
bioRxiv · Sep 27, 2026 · PreprintBioinformatics
Genome-wide mapping of persistent long-range correlation in the complete telomere-to-telomere human reference genome
Kleio Papatheodorou, Georgios Megalovasilis, Apostolos Zaravinos, Ilias Georgakopoulos‐Soares
The paper maps long-range correlations in the complete telomere-to-telomere human genome, revealing heterogeneous genomic structure and chromosome-specific scaling.
bioRxiv · Jul 19, 2026 · PreprintGenomics
Entropy Fusion DNA: Alignment-Free Gene Fusion Detection through Entropy and Mutual Information Descriptors
Gerardo Benevento, Delfina Malandrino, Alessia Ture, Rocco Zaccagnino
This paper introduces an alignment-free method using information-theoretic features to detect gene fusions, achieving strong performance in classification and partner prediction.
bioRxiv · May 30, 2026 · PreprintBioinformatics
In silico restriction site analysis of whole genome sequences shows patterns caused by selection and sequence duplications
The paper analyzes whole genome sequences to identify non-random patterns in restriction site distributions, showing deviations from random sequences and effects of GC content and repetitive elements.
bioRxiv · May 16, 2026 · PreprintGenomics
Quaternion Spectral Fingerprinting of DNA: GPU-Accelerated Multi-Channel Fourier Analysis for Alignment-Free Genomics
This paper introduces a quaternion Fourier transform framework for DNA sequence analysis, demonstrating its ability to detect structural periodicities and spectral signatures across multiple species.
bioRxiv · Apr 9, 2026 · PreprintBioinformatics
Proteins as Statistical Languages: Information-Theoretic Signatures of Proteomes Across the Tree of Life
The paper introduces information-theoretic descriptors to analyze protein sequences as statistical languages, showing that real proteomes exhibit structured dependencies beyond simple compositional models.
bioRxiv · Feb 8, 2026 · PreprintBioinformatics
dna-parser: a Python library written in Rust for fast encoding of DNA and RNA sequences
Matthieu Vilain, Stéphane Aris‐Brosou
dna-parser encodes DNA and RNA sequences into numerical features efficiently using Rust and Python, offering fast and parallel processing.
bioRxiv · Jan 21, 2026 · PreprintBioinformatics
UniWave: A Waveform-Based Encoding Framework for Nucleic Acid Feature Extraction
Hao Zhang, Yujun Qi, Lili Wang
UniWave converts nucleotide sequences into continuous waveforms for improved genomic analysis, outperforming traditional methods in multiple tasks.
bioRxiv · Jan 13, 2026 · PreprintBioinformatics
Efficient training of neural networks using natural vectors with covariates for the plant microRNA precursor prediction.
Javier Israel Montalvo-Arredondo, Marco A. Juárez-Verdayes
This study evaluates neural networks trained with natural vectors incorporating covariance for predicting plant microRNA precursors, showing improved performance in feature prediction and classification.
bioRxiv · Jan 9, 2026 · PreprintBioinformatics
High dimensional tissue specific regulatory codes embedded in viral coding regions
Alma Davidson, Marina Parr, Franziska Totzeck, Alexander Churkin, Danny Barash, Dmitrij Frishman, Tamir Tuller
This study shows that high dimensional silent patterns in viral coding regions encode regulatory codes related to viral tropism using a novel computational measure.
bioRxiv · Dec 27, 2025 · PreprintSystems Biology
Discovery of Inverted Repeats and Palindromes in Viral Genomes
Madhura Sen, G. Rivera, Jingxiang Gao, Matthew Shtrahman, Madhavi K. Ganapathiraju
The paper identifies over 19 million inverted repeats in 14,000 viral genomes using BLMT, highlighting their prevalence and potential biological significance.
bioRxiv · Nov 10, 2025 · PreprintBioinformatics
A DNA Sequence Imaging Approach to Predict Splice Sites Using Deep Learning
Espoir K. Kabanga, Seonil Jee, Arnout Van Messem, Wesley De Neve
This paper introduces a DNA sequence imaging method for splice site prediction, showing that DFCP outperforms FCGR using deep learning on Arabidopsis and human data.
bioRxiv · Jun 24, 2025 · PreprintBioinformatics
Frequency Chaos Game Representation - Singular Value Decomposition for Alignment-Free Phylogenetic Analysis
Varsha Achuthan, Deeptangi Mangsuli, Neelam Sinha, Shweta Ramdas
This paper introduces SVD-FCGR, an alignment-free phylogenetic analysis method using SVD on FCGR, showing improved resolution and scalability over MEGA for viral datasets.
bioRxiv · Apr 16, 2025 · PreprintBioinformatics
Musical Insights into Protein Sequences and Functions via NMR Data
Zahra Moosavi-Movahedi, Parinaz Lordifard, Ramin Akhavijou, Kaveh Kavousi, Shohreh Ariaeenejad, Reza Beh-Afarin, Amir Mohammad Mortazavian, Abbas Shockravi, Ali Akbar Moosavi‐Movahedi
This paper converts protein sequences into music using NMR data, assigning notes based on amino acid frequencies and relaxation periods, and applies set theory to analyze homologous beta-globin sequences.
bioRxiv · Mar 9, 2025 · PreprintBioinformatics
TIPs-VF: An augmented vector-based representation for variable-length DNA fragments with sequence, length, and positional awareness
TIPs-VF provides a variable-length DNA sequence encoding framework that improves representation of genetic sequences for machine learning by incorporating sequence, length, and positional awareness.
bioRxiv · Feb 15, 2025 · PreprintBioinformatics
Prioritization of Lung Cancer Candidate Genes using Moment of Inertia Tensor Analysis
Ayushi Dwivedi, Mallikarjuna Thippana, P. Manimaran, Vaibhav Vindal
This study prioritizes lung cancer candidate genes using moment of inertia tensor analysis of amino acid physicochemical properties, identifying four genes linked to poor survival.
bioRxiv · Oct 18, 2024 · PreprintBioinformatics
Improved Python Package for DNA Sequence Encoding using Frequency Chaos Game Representation
Abhishek Halder, Piyush Piyush, Bernadette Mathew, Debarka Sengupta
The paper introduces a Python package for DNA sequence encoding using Frequency Chaos Game Representation (FCGR), showing improved accuracy and efficiency over an R-based library for DNA sequences.
bioRxiv · Apr 14, 2024 · PreprintBioinformatics
Complexity And Ergodicity In Chaos Game Representation Of Genomic Sequences
Adel Mehrpooya, Iman Tavassoly
The paper analyzes the Chaos Game Representation of genomic sequences to assess ergodicity and finds that CGRs are non-ergodic due to distribution properties of nucleotide sequences.
bioRxiv · Dec 30, 2023 · PreprintBioinformatics
Development of a fast feature extraction method for SARS-CoV-2 spike sequences using amino acid physicochemical properties
Hiroya Oka, Kosaku Noba, Jun Sasahara, Takayuki Hashimoto, Shogo Yoshimoto, Hirohiko Niioka, Jun Miyake, Katsutoshi Hori
This paper develops a fast feature extraction method for SARS-CoV-2 spike sequences using amino acid physicochemical properties, achieving accurate clustering with reduced runtime compared to conventional methods.
bioRxiv · Nov 18, 2023 · PreprintBioinformatics
Analysis of Sequences of Bases of Human DNA Using the Square Wave Method (SWM)
Osvaldo Skliar, Sherry E. Gapper, Ricardo E. Monge
The paper describes the application of the Square Wave Method to analyze human DNA sequences and presents preliminary data supporting its potential functional relevance.
bioRxiv · Nov 13, 2023 · PreprintGenomics
In-Silico analysis of Human Insulin Gene for Mirror repeat sequences
Manisha Yadav, Barkha Sehrawat, Pooja Yadav, Jyoti Kumari, Priyanka Yadav, Shivani Yadav, Rachna Yadav, A.D. Singh, Sandeep Yadav
The paper identifies 210 mirror repeat sequences in the human insulin gene using an in silico approach called FPCB.
bioRxiv · Jul 10, 2023 · PreprintBioinformatics
ortho_seqs: A Python tool for sequence analysis and higher order sequence-phenotype mapping
Saba Nafees, Venkata N. P. Vemuri, Miles Woollacott, Ahmet Can Solak, Phoenix Logan, Aaron McGeever, Olivia Yoo, Sean H. Rice
ortho_seqs quantifies sequence-phenotype interactions using tensor-based orthogonal polynomials, demonstrating its application to synthetic antibody sequences and other datasets.
bioRxiv · Sep 14, 2022 · PreprintBioinformatics
Sequence-based Optimized Chaos Game Representation and Deep Learning for Peptide/Protein Classification
Beibei Huang, Eric Zhang, Rajan R. Chaudhari, Heiko Gimperlein
The paper develops a sequence-based chaos game representation combined with deep learning for peptide/protein classification, showing superior performance in hemolytic/non-hemolytic peptide and HIV protease mutant classification.
bioRxiv · Sep 10, 2022 · PreprintBioinformatics
The Geometry of ATG-Walks of the Omicron SARS CoV-2 Virus RNAs
The paper analyzes ATG-walks of Omicron SARS-CoV-2 RNA sequences to compare their statistical characteristics with a reference RNA, finding small deviations and resistance to forming a new virus family.
bioRxiv · Dec 20, 2021 · PreprintGenomics
Nfeature: A platform for computing features of nucleotide sequences
Megha Mathur, Sumeet Patiyal, Anjali Dhall, Shipra Jain, Ritu Tomer, Akanksha Arora, Gajendra P. S. Raghava
Nfeature computes a large number of features for DNA and RNA sequences, providing a standalone package and web platform for researchers.
bioRxiv · Dec 14, 2021 · PreprintBioinformatics
Deep learning based on stacked sparse autoencoder applied to viral genome classification of SARS-CoV-2 virus
Maria G. F. Coutinho, Gabriel Bezerra Motta Câmara, Raquel de Melo Barbosa, Marcelo A. C. Fernandes
This paper applies stacked sparse autoencoders to classify SARS-CoV-2 genomes using k-mer image representations, achieving good performance in taxonomic classification.
bioRxiv · Oct 14, 2021 · PreprintBioinformatics
DiviSSR: Simple arithmetic for efficient identification of tandem repeats
Akshay Kumar Avvaru, Rakesh K. Mishra, Divya Tej Sowpati
DiviSSR uses a mathematical property of 2-bit DNA representations to quickly and accurately identify tandem repeats in genomic data.
bioRxiv · Oct 5, 2021 · PreprintBioinformatics
GBRAP: a tool to retrieve, parse and analyze GenBank files of viral and bacterial species
Chiara Vischioni, Valério Giaccone, Paolo Catellani, Leonardo Alberghini, Riccardo Miotti Scapin, Cristian Taccioli
GBRAP is a Python tool that downloads, parses, and analyzes GenBank files for viral and bacterial genomes, providing various entropy and compositional analyses.
bioRxiv · Sep 21, 2021 · PreprintBioinformatics