Topic · Cell Biology · Biochemistry, Genetics and Molecular Biology

Calpain Protease Function and Regulation

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain

Teng Wei Koay, Carina Osterhof, Angèle Clerc, David Hoogewijs

This study identifies calcium-dependent proteolysis of ADGB and altered localization of its isolated globin domain, revealing new regulatory mechanisms.

Journal of Biological Chemistry · Sep 18, 2026Peer-reviewedCell Biology

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

S. Sadia Ameen, Nane Griem‐Krey, Antoine Dufour, Mohammed Iqbal Hossain, Ashfaqul Hoque, Sharelle A. Sturgeon, Harshal H. Nandurkar, Dominik F. Draxler, Robert Lindsay Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep S. Dhillon, Jet Phey Lim, , Heung‐Chin Cheng

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.

Molecular & Cellular Proteomics · Apr 6, 2023Peer-reviewedNeuroscience