N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection
S. Sadia Ameen, Nane Griem‐Krey, Antoine Dufour, Mohammed Iqbal Hossain, Ashfaqul Hoque, Sharelle A. Sturgeon, Harshal H. Nandurkar, Dominik F. Draxler, Robert Lindsay Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep S. Dhillon, Jet Phey Lim, , Heung‐Chin Cheng
The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.
Molecular & Cellular Proteomics · Apr 6, 2023Peer-reviewedNeuroscience