Author

Isabelle S. Lucet

The University of MelbourneORCID 0000-0002-8563-8753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Amardeep S. DhilloniD· 1 shared Andrew N. ClarksoniD· 1 shared Andrew P. ThompsoniD· 1 shared Anthony T. PapenfussiD· 1 shared Antoine DufouriD· 1 shared Ashfaqul HoqueiD· 1 shared Carli L. Roulston· 1 shared Ching‐Seng AngiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Amardeep S. DhillonORCID

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2 papers

Recent·Most cited

ProteinDJ: a high-performance and modular protein design pipeline

Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy

ProteinDJ is a high-performance protein design pipeline that enables efficient generation and testing of synthetic protein binders using HPC systems.

Protein Science · Jan 21, 2026Peer-reviewedBioinformatics

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

S. Sadia Ameen, Nane Griem‐Krey, Antoine Dufour, Mohammed Iqbal Hossain, Ashfaqul Hoque, Sharelle A. Sturgeon, Harshal H. Nandurkar, Dominik F. Draxler, Robert Lindsay Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep S. Dhillon, Jet Phey Lim, , Heung‐Chin Cheng

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.

Molecular & Cellular Proteomics · Apr 6, 2023Peer-reviewedNeuroscience