Calpain Protease Function and Regulation

Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain

This study identifies calcium-dependent proteolysis of ADGB and altered localization of its isolated globin domain, revealing new regulatory mechanisms.

Proposed core role for cytosolic and transmembrane calpain cysteine proteases in mitotic cell divisions

The paper proposes a core role for cytosolic and transmembrane calpains in cytokinesis by organizing microtubules during cell division in plants and animals.

Calpain-4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Alcohol-Related Liver Disease

This study shows that Calpain-4 knockdown reduces cholesterol levels and relocalizes LXRα to the nucleus in alcohol-related liver disease.

Identification and neuroprotective properties of NA-184, a selective calpain-2 inhibitor

The paper identifies NA-184, a selective calpain-2 inhibitor, and shows its neuroprotective effects in traumatic brain injury models.

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.

MRI of Capn15 knockout mice and analysis of Capn15 distribution reveal possible roles in brain development and plasticity

The paper uses MRI and beta-galactosidase expression to study Capn15 knockout mice, revealing brain size reductions and expression patterns in adult mice.