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RhoBAST-FLIM improves RNA imaging by using fluorescence lifetime differences to enhance contrast and resolution in live cells.

This paper introduces SpliceRACER, a modular RNA switch platform that enables multiplexed, orthogonal, and combinatorial gene regulation in mammalian cells through alternative splicing, achieving 27 discrete expression states.

This paper develops a low-cost, multi-nozzle 3D bioprinter capable of printing up to 10 different bioinks with high positional accuracy and repeatability.

BOWIe is a wireless headstage for optogenetics in freely-moving rodents, enabling simple integration with behavioral setups and closed-loop operation.

This paper introduces a physics-informed neural network to predict myocardial mechanics from physiological measurements, showing improved stress prediction and disease stratification in pulmonary hypertension.

This paper integrates broadband light stimulation into bioprinting to enhance osteogenic differentiation and vascularisation in 3D cell cultures.

This paper introduces an improved SS-vis-OCT system with extended imaging depth and sensitivity for biological samples.

FluOpti enables programmable optogenetics and multi-fluorescence imaging across whole petri dishes to study spatial gene network dynamics in bacterial colonies.

This paper develops a real-time ultrafast holography method for imaging focused ultrasound fields using an ultrasound scanner, achieving accurate wave field reconstruction and dual-mode imaging.

CRADLE-1 automates protein lead optimization, improving speed and efficiency compared to rational design methods.

This study decouples the effects of sex chromosomes and gonadal sex on cardiac myofibroblast activation using FCG mice and hydrogel cultures, revealing sex-specific gene and protein expression patterns.

This study shows that XWRAP, a proprietary processed placental tissue allograft, maintains greater graft integrity and reduces the need for reapplication compared to conventional and commercial comparators.

The paper introduces HSMV, a dataset of human sperm microscopy videos for detection, tracking, and motility analysis, with annotated and unannotated clips for algorithm benchmarking.

This study develops a deformable lung airway model to assess how airway deformation and carrier gas affect aerosol transport and deposition in the respiratory system.

This study develops and tests nano-prodrugs of indole-3-propionic acid (IPA) to treat experimental autoimmune arthritis, showing improved lymphoid exposure and immunomodulatory effects.

CaGE alternates guided structure prediction with sequence redesign, fading guidance each cycle, so sequences recover complex catalytic sites unaided; designed nonheme-iron and PLP-dependent enzymes were active.

Proteo-Seq links chromatin accessibility and proteomic output in the same cell, revealing new protein-defined states in breast cancer cells.

This paper benchmarks six hyperspectral denoising methods for BCARS images using variance-stabilized data, finding that CCV offers a balance of speed and accuracy.

The paper introduces MESSI, a generative diffusion model for deimmunizing proteins by designing sequences with minimal immunogenicity while preserving structure and function.

This paper estimates glucose levels from PPG signals using feature selection and machine learning, finding modest predictive power but below clinical standards.