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Deep learning-based prediction of wall shear stress throughout the cardiac cycle in middle cerebral artery bifurcation aneurysms

This paper develops a deep learning framework called STEP to predict cardiac-cycle wall shear stress in aneurysms using pre-trained steady-flow models and transient fine-tuning.

Noise-Aware Constitutive Compatibility Atlas for Hyperelastic Material Characterization

The paper develops a noise-aware constitutive-response atlas to identify compatible hyperelastic material models within a deformation range and error tolerance, using both synthetic and real-world datasets.

Inoculum-to-interface distance tunes productivity in static liquid cultures of wood-decay fungi

This study identifies the distance between fungal biomass and the liquid-air interface as a key factor in pellicle formation in static liquid cultures, showing that reducing this distance accelerates and stabilizes formation.

Functional recovery of vitrified and nanowarmed human-scale pig kidneys

This study demonstrates functional recovery of human-scale porcine kidneys after long-term cryogenic storage using vitrification and nanowarming.

A Triple-Measure Model for Estimating Cranial-Brain Size Across Age Groups

This paper develops a non-invasive model called the Triple-Measure to estimate endocranial volume, showing better correlation than head circumference alone across age groups.

Hydrogel microneedle patch for low-cost, colorimetric, continuous glucose monitoring

This paper develops a low-cost, colorimetric microneedle hydrogel patch for continuous glucose monitoring, showing accurate color changes in response to glucose levels.

Panvascular-JEPA: Unseen-Structure Evaluation of Factorized Predictive States for Hemodynamic Networks

The paper evaluates predictive models for hemodynamic networks on unseen structures, comparing their performance against known equations and finding neural models underperform compared to traditional methods.

Thermoplastic polyurethane as a base material for soft, high-density neural interfaces

This paper introduces thermoplastic polyurethane (TPU) as a base material for soft, high-density neural interfaces and demonstrates its fabrication and biocompatibility.

Matrix-modulated Air-liquid Interface Microenvironments Reveal Architectural Control of Lung Tumor Phenotypes

This study shows that combining air-liquid interface, extracellular matrix, and 3D architecture in vitro models produces distinct lung tumor phenotypes not seen in standard 2D or submerged 3D cultures.

Chronic Electrophysiology Captures Progressive Variability in DNA-Damaged Cardiac Networks

This study uses chronic electrophysiological recordings to track progressive changes in cardiac function in iPSC-CM monolayers exposed to doxorubicin, revealing spatial and temporal variability in electrical activity.

Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils Derived from Human Pluripotent Stem Cells

This study develops hPSC-derived FAP CAR neutrophils to target cardiac fibrosis, showing in vitro cytotoxicity and improved left ventricular ejection fraction in a mouse MI model.

A robust and scalable image analysis framework for phenotyping human thoracic aorta

This paper introduces a framework for automated thoracic aorta phenotyping from CT scans, generating anatomical landmarks, meshes, and biomechanical phenotypes.

The ammonia-senescence ratchet drives an adaptation-senescence-ammonioptosis transition in liver cancer

This study identifies an ammonia-senescence ratchet mechanism that drives tumor cells from metabolic adaptation to senescence and ultimately to ammonioptosis.

A Novel Computational Framework to Investigate the Biomechanics of Burrowing

This paper develops a computational framework combining DEM and FEA to study cranial biomechanics during burrowing in Blanus cinereus, showing how soft tissues and cranial sutures manage mechanical loads.

Pocket-Conditioned Generation and Down-Selection of Non-Oxime Reactivators

This paper compares generative models for designing non-oxime reactivators of paraoxon-inhibited acetylcholinesterase, finding that down-selection methods outperform DrugDiff in practical drug-likeness and synthesis feasibility.

A StayGold-based calcium ion indicator

The paper develops a new calcium indicator, HiCaRI, based on the photostable mStayGold protein, showing improved brightness and photostability compared to existing GFP-based indicators.

Nose-to-Knee Transplantation for Osteochondral Regeneration: A Proof-of-Concept Study in Sheep Employing Ceramic-Hydrogel Osteochondral Grafts

This study develops autologous osteochondral grafts in sheep using nasal chondrocytes and 3D-printed scaffolds, showing mechanical maturity but limited integration due to implant sinking.

In Vitro Assessment of Chemically Modified Probiotic Bacteria as Receptor-Mimic Decoys for Cholera Toxin B Subunit

This study develops GM1-receptor-mimic probiotic bacteria that bind and sequester cholera toxin B subunit in vitro, reducing its binding to host cells.

Inherent limitations of zero-shot mutation prediction in protein engineering

This study evaluates zero-shot mutation prediction models in protein engineering, finding they struggle to identify optimal mutations and predict new functions due to limitations in capturing evolutionary constraints.

FLEX-DBS: a flexible wireless platform for bilateral constant-current deep brain stimulation in freely moving rodents

FLEX-DBS is a wireless stimulator for bilateral DBS in rodents, offering programmable stimulation parameters and autonomous operation, with results showing increased immobility during high-amplitude stimulation.