Discover, rate, and discuss biology preprints.

The paper develops qLAMP and RT-qLAMP assays for detecting five BRD-associated viruses with high sensitivity and specificity, and introduces a streamlined pipeline for assay development.

The paper develops a human brain vasculature-on-a-chip model using microvessels from postmortem tissue, demonstrating anatomical and physiological features of the blood-brain barrier.

The paper introduces CoBiSe, a computational method for biosensor design, and demonstrates its application in creating IronSenseR, a biosensor for ferrous iron with high specificity and sensitivity.

The paper develops a multiplexed single-cell approach to monitor CRISPR-induced genotoxicity and shows that palbociclib reduces genomic rearrangements in hematopoietic cells.

This paper introduces a thermodynamics-first approach to molecular computation using the TBN model, demonstrating systems that perform Boolean logic and concatemer synthesis.

This study uses direct fiber modeling to capture specimen-specific 3D collagen fiber architecture and anisotropic mechanics of sclera samples under various loadings.

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

This paper introduces a method to create 3D-printed reference structures with X-ray contrast agents for precise multimodal fusion of microCT and histology.

This paper develops a lactate/oxygen enzymatic biofuel cell using laser-induced graphene electrodes for real-time wearable biosensing, showing linear power density increase with lactate concentration.

This paper develops an in vitro model of the human CNS to study intrathecal drug dispersion and pharmacokinetics, providing reliable data for therapy design.

The paper models biomechanical factors affecting metabolic rate during walking with a powered ankle-foot prosthesis using machine learning, identifying key features that significantly influence metabolic rate.

This paper develops ultrasound-transparent neural interfaces that enable compatibility with functional ultrasound imaging and therapy, validated through simulations and experiments.

This study compares three microfluidic fabrication techniques for producing silk fibroin microgels with tunable properties, finding each method has unique advantages and limitations.

The paper demonstrates neuromodulation in neural organoids using 3D shell MEAs, showing increased neuron firing rates with specific stimulation ranges.

This study uses optical imaging to show rapid rod photoreceptor contraction after photoisomerization, linking it to the early receptor potential and demonstrating a voltage-dependent membrane tension model.

This study shows that extracellular vesicles from GLUT4-overexpressing engineered muscle tissue improve glucose uptake and insulin sensitivity in T2D mice.

This study shows that unmodified mRNA can be used for CAR-T cell engineering without compromising function, eliminating the need for costly nucleoside modifications.

This study develops computational hemodynamic indices to predict Structural Valve Deterioration in TAVI patients using personalized simulations and clinical data.

The paper introduces a microfluidic platform for high-throughput generation of uniform intestinal organoids in hydrogel droplets, achieving high homogeneity and reproducibility.