Discover, rate, and discuss biology preprints.

The paper predicts a radical-based pathway for peptide bond formation under prebiotic conditions, showing it could occur without complex catalysts and with low energy barriers.

The paper introduces SFinx, a framework for spatial functional analysis of transcriptomic data, revealing spatially varying pathway interactions in lupus nephritis.

AINN-Express predicts VHH antibody expression using only sequence data, achieving high ROC-AUC scores in both known and new programs without requiring structural data or task-specific training.

EXCAVATE-HT identifies targetable genomic variants for allele-specific CRISPR editing by analyzing population data and generating gRNA libraries.

DOME Copilot automates the generation of transparent AI methodology reports for life science publications, matching or exceeding manual quality while reducing creation time.

This study reformulates logistic regression for high-dimensional gene expression data, achieving clear separation between control and disease groups while selecting relevant features.

MeioBIOME is a Snakemake pipeline for analyzing holobiont metagenomes from single meiofaunal specimens, generating host-associated MAGs and SCGs.

This paper introduces GiG, a graph AI framework that integrates and interprets whole-person medical and omics data to prioritize biomarkers and improve disease diagnosis.

CNVeil infers haplotype-specific copy number and subclonal architecture from single-cell cancer genomes, outperforming existing methods in accuracy and resolution.

The paper introduces BIP, a pipeline for DNA barcode inference from sequencing data, which outperforms existing tools by accurately distinguishing target and non-target sequences.

The paper introduces an automated pipeline for whole-genome sequencing analysis of microbial pesticides to improve hazard characterization and risk assessment.

GatorPrism integrates spatial multi-omics data by balancing cross-omics consensus with modality-specific signals, achieving strong performance across clustering metrics and revealing tissue structure organization.

VizR provides an interactive web platform for end-to-end RNA-seq analysis and visualization in plant biology, reducing technical barriers through automation and integration.

The paper designs water-soluble analogs of EBV membrane proteins using QTY residues, showing minimal structural changes and reduced hydrophobicity.

The paper uses deconvolution of bulk RNA-seq to generate cell-type-specific targets for predicting gene expression from personal genome sequences, finding that sequence-derived models outperform genotype-feature baselines.

CHIMIYA-1 is a foundation model for ADMET property prediction that outperforms many public methods on the TDC ADMET benchmark, with strong performance on toxicity and physicochemical endpoints.

PhytoFam automates plant gene family analysis through a Nextflow pipeline, integrating multiple tools for homolog detection, orthology assignment, and phylogenetic reconstruction.

GraTools is a command-line tool for manipulating pangenome variation graphs, enabling efficient subgraph extraction, sequence retrieval, and analysis of genomic diversity.

GeneKnow synthesizes biological evidence from literature with auditability, achieving higher claim support and citation fidelity than existing AI systems.

GenoSim simulates diploid SNP genotypes with population stratification and pedigree constraints, providing outputs compatible with clinical and population genetics formats.