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This study reconstitutes lipid nanoparticle-mediated siRNA transfer across endosomal membranes using GUVs, showing siRNA can translocate without membrane rupture or pH gradient loss.

This study shows that Lac1-dependent ceramide synthesis is essential for proper septum assembly and cell separation in fission yeast.

The paper identifies a self-renewing lymphoid-biased HSC subset in mice that maintains lymphopoiesis during aging and may serve as a backup source for immune function.

This study shows that selenocysteine (Sec) plays a role in protein folding during biosynthesis, not just in mature proteins, by demonstrating that its incorporation affects dimer formation in SELENOM.

This study shows that galectin-3's carbohydrate recognition domain maintains plasma membrane phosphatidylserine, which is necessary for KRAS function.

The paper uses advanced imaging techniques to study how multiple organelles coordinate during T cell killing, revealing a calcium-driven process of organelle assembly and movement.

This study identifies 'unlatching' as a common mechanism for Parkinson's disease-associated LRRK2 variants, showing increased membrane localization and decreased S935 phosphorylation.

The paper shows that rigid tissue environments enhance DNA repair efficiency and may contribute to cancer risk by promoting survival of damaged cells.

This study identifies SFA1's role in coordinating cytoskeletal organisation, apical polarity, and cell replication during Plasmodium sexual development, showing its necessity for parasite transmission.

This study characterizes the spatiotemporal proliferative response of endothelial cells in acute liver injury and introduces a novel pipeline for analyzing hepatic cell states.

This study uses MINFLUX nanoscopy to show nuclear speckles are hierarchically organized into dynamic nanoscale interaction networks that regulate molecular dynamics.

This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

This study evaluates the immunotoxic effects and metabolism of enniatins and beauvericin in human intestinal models, finding limited acute toxicity but distinct inflammatory responses and transport differences.

This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.

The paper uses expansion microscopy to reveal the repeat-subunit organization and multi-domain architecture of human mitotic centromeres, including specialized histone modifications.

This study examines how different concentrations and durations of cigarette smoke condensate exposure affect oxidative stress, autophagy, EMT, and cell death in human and mouse RPE cells.

SACHET tracks individual endosomes in live cells to quantify Rab conversion kinetics, showing rapid switching between Rab5 and Rab7 states across cell lines.

The paper identifies sub-micron actin ridges on macrophages that facilitate phagocytosis of encapsulated fungal pathogens like Cryptococcus neoformans.

This study tracks antisense oligonucleotides (ASOs) through endocytic trafficking, finding that productive escape occurs early in endosomes before sequestration in late compartments.

This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.